Protein-coding gene in the species Homo sapiens
PDE4D Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU
Identifiers Aliases PDE4D , ACRDYS2, DPDE3, HSPDE43, PDE4DN2, STRK1, phosphodiesterase 4DExternal IDs OMIM: 600129; MGI: 99555; HomoloGene: 129755; GeneCards: PDE4D; OMA:PDE4D - orthologs Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2-q12.1 Start 58,969,038 bp[1] End 60,522,120 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.1|13 59.69 cM Start 108,586,482 bp[2] End 110,089,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes muscle of arm biceps brachii Skeletal muscle tissue of rectus abdominis triceps brachii muscle Skeletal muscle tissue of biceps brachii thoracic diaphragm Achilles tendon gastrocnemius muscle vastus lateralis muscle
Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle olfactory bulb Cortex of frontal lobe right kidney proximal tubule superior frontal gyrus primary visual cortex thymus
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
ATPase binding
scaffold protein binding
cAMP binding
metal ion binding
beta-2 adrenergic receptor binding
protein binding
phosphoric diester hydrolase activity
enzyme binding
hydrolase activity
ubiquitin protein ligase binding
transmembrane transporter binding
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
Cellular component
cytoplasm
cytosol
centrosome
microtubule organizing center
apical plasma membrane
cytoskeleton
membrane
calcium channel complex
voltage-gated calcium channel complex
plasma membrane
nuclear membrane
Biological process
establishment of endothelial barrier
smooth muscle contraction
positive regulation of interleukin-5 production
multicellular organism growth
human ageing
regulation of signaling receptor activity
positive regulation of interferon-gamma production
neutrophil chemotaxis
positive regulation of interleukin-2 production
regulation of cell communication by electrical coupling involved in cardiac conduction
adrenergic receptor signaling pathway
cellular response to lipopolysaccharide
T cell receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
cAMP-mediated signaling
cellular response to cAMP
signal transduction
leukocyte migration
negative regulation of relaxation of cardiac muscle
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
negative regulation of heart contraction
regulation of heart rate
regulation of ryanodine-sensitive calcium-release channel activity
cAMP catabolic process
cellular response to epinephrine stimulus
regulation of cardiac muscle cell contraction
negative regulation of peptidyl-serine phosphorylation
G protein-coupled receptor signaling pathway
negative regulation of cAMP-mediated signaling
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001104631 NM_001165899 NM_001197218 NM_001197219 NM_001197220 NM_001197221 NM_001197222 NM_001197223 NM_006203 NM_001349241 NM_001349242 NM_001349243 NM_001364599 NM_001364600 NM_001364601 NM_001364602 NM_001364603 NM_001364604
RefSeq (protein) NP_001098101 NP_001159371 NP_001184147 NP_001184148 NP_001184149 NP_001184150 NP_001184151 NP_001184152 NP_006194 NP_001336170 NP_001336171 NP_001336172 NP_001351528 NP_001351529 NP_001351530 NP_001351531 NP_001351532 NP_001351533
NP_035186 NP_001389812 NP_001389813 NP_001389814 NP_001389815 NP_001389816 NP_001389817
Location (UCSC) Chr 5: 58.97 – 60.52 Mb Chr 13: 108.59 – 110.09 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.
^ a b c GRCh38: Ensembl release 89: ENSG00000113448 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
Last Update: 2024-03-27T22:11:09Z
phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene. The PDE4D gene is complex and has at least 9 different isoforms that encode...
Word Count : 1812
Last Update: 2022-07-02T11:15:40Z
types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'-cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor...
Word Count : 59
Last Update: 2024-02-25T21:30:43Z
believed to be caused by mutations in the PRKAR1A gene (type 1) or the PDE4D gene (type 2). It has been suggested that the condition might be genetically...
Word Count : 588
Last Update: 2024-03-10T06:33:45Z
of DEPDC1B includes 5 other genes. Downstream are two genes SEPT21 and PDE4D . Upstream are another two genes ELOV7 and KRT8P31. On the complement strand...
Word Count : 2261
Last Update: 2023-12-07T20:38:57Z
PDE1B, PDE1B2, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4B5, PDE4C, PDE4D , PDE5A, PDE6A, PDE6B, PDE6C, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PDE10A,...
Word Count : 821
Last Update: 2023-12-03T16:24:32Z
FRA4E FRA4F (GRID2 gene) FRA5A FRA5B FRA5C FRA5D FRA5E FRA5F FRA5G FRA5H (PDE4D gene) FRA6A FRA6B FRA6C FRA6D FRA6E (PARK2 gene) FRA6F FRA6G FRA6H FRA7A...
Word Count : 2523
Last Update: 2024-03-27T22:09:21Z
Conti M (1995). "Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4". Cytogenetics...
Word Count : 1442
Last Update: 2024-04-11T10:03:20Z
receptor, CD18, CD29 Cyclin A1 EIF6, FYN, IFNAR2, Janus kinase 1 OTUB1, P73, PDE4D , PRKCB1, PRKCE, PTPRM, RAS p21 protein activator 1, ST7, STAT1, Src, and...
Word Count : 2598
Last Update: 2024-01-03T00:49:21Z
brain size evolution. Myomegalin (PDE4DIP) has been shown to interact with PDE4D . The protein was discovered in 2000 and was so named because it was highly...
Word Count : 989
Last Update: 2023-08-24T00:42:22Z
formed by the conserved glutamine (Q817 in PDE5A, Q443 in PDE4B and Q369 in PDE4D ) and the P clamp (a hydrophobic clamp at the narrow side of the active sites...
Word Count : 4750
Last Update: 2023-03-07T02:43:16Z
inhibitors residing in the active site. The co-crystal structures for PDE4B, PDE4D and PDE5A have revealed two common features of inhibitor binding to PDEs...
Word Count : 2872