Receptor for activated C kinase 1 information

RACK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AOW, 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX
Identifiers
Aliases	RACK1, Gnb2-rs1, H12.3, HLC-7, PIG21, GNB2L1, receptor for activated C kinase 1
External IDs	OMIM: 176981; MGI: 101849; HomoloGene: 4446; GeneCards: RACK1; OMA:RACK1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	181,248,096 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	48,697,261 bp
RNA expression pattern
	Top expressed in
	pericardium; ; superior surface of tongue; ; body of tongue; ; mucosa of pharynx; ; vena cava; ; nipple; ; saphenous vein; ; trachea; ; lower lobe of lung; ; cerebellar vermis;
	Top expressed in
	epiblast; ; ventricular zone; ; bone marrow; ; ovary; ; ganglionic eminence; ; spleen; ; uterus; ; zone of skin; ; placenta; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; receptor tyrosine kinase binding; SH2 domain binding; signaling adaptor activity; protein tyrosine kinase inhibitor activity; protein binding; enzyme binding; cysteine-type endopeptidase activator activity involved in apoptotic process; molecular adaptor activity; protein phosphatase binding; signaling receptor binding; ion channel inhibitor activity; RNA binding; cadherin binding; ribosome binding; protein kinase C binding; cyclin binding;
Cellular component	cytoplasm; cell body; perikaryon; cell projection; membrane; plasma membrane; neuronal cell body; dendrite; midbody; mitochondrion; perinuclear region of cytoplasm; neuron projection; phagocytic cup; extracellular exosome; nucleus; IRE1-RACK1-PP2A complex; nucleoplasm; cytosol; ribosome; small ribosomal subunit; cytosolic small ribosomal subunit;
Biological process	positive regulation of protein homooligomerization; positive regulation of Golgi to plasma membrane protein transport; negative regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of ceramide biosynthetic process; regulation of cell division; negative regulation of phagocytosis; positive regulation of gastrulation; rhythmic process; positive regulation of cell migration; negative regulation of endoplasmic reticulum unfolded protein response; cellular response to growth factor stimulus; negative regulation of Wnt signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of gene expression; regulation of cell cycle; regulation of protein localization; multicellular organism development; positive regulation of GTPase activity; negative regulation of hydrogen peroxide-induced neuron death; positive regulation of mitochondrial depolarization; gastrulation; negative regulation of cell growth; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptotic process; cell cycle; regulation of growth; viral process; regulation of establishment of cell polarity; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; regulation of translation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cellular response to glucose stimulus; positive regulation of cyclic-nucleotide phosphodiesterase activity; apoptotic process; negative regulation of protein tyrosine kinase activity; protein biosynthesis; pigmentation; protein ubiquitination; rescue of stalled ribosome; negative regulation of translation; regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10399
	14694
	ENSG00000204628
	ENSMUSG00000020372
	P63244
	P68040
	NM_006098
	NM_008143
	NP_006089
	NP_032169
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor for activated C kinase 1 (RACK1), also known as guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), is a 35 kDa protein that in humans is encoded by the RACK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204628 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020372 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (February 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proceedings of the National Academy of Sciences of the United States of America. 91 (3): 839–43. Bibcode:1994PNAS...91..839R. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854.
^ Guillemot F, Billault A, Auffray C (June 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proceedings of the National Academy of Sciences of the United States of America. 86 (12): 4594–8. Bibcode:1989PNAS...86.4594G. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204628 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020372 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ron_1994-5] Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (February 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proceedings of the National Academy of Sciences of the United States of America. 91 (3): 839–43. Bibcode:1994PNAS...91..839R. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854.

[pmid2499885-6] Guillemot F, Billault A, Auffray C (June 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proceedings of the National Academy of Sciences of the United States of America. 86 (12): 4594–8. Bibcode:1989PNAS...86.4594G. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885.

Receptor for activated C kinase 1 information

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