Myomegalin information

PDE4DIP
Identifiers
Aliases	PDE4DIP, CMYA2, MMGL, phosphodiesterase 4D interacting protein
External IDs	OMIM: 608117; MGI: 1891434; HomoloGene: 66961; GeneCards: PDE4DIP; OMA:PDE4DIP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,048,286 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	97,796,023 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; right auricle; ; right hemisphere of cerebellum; ; Achilles tendon; ; gastric mucosa; ; right frontal lobe; ; popliteal artery; ; tibial arteries;
	Top expressed in
	muscle of thigh; ; spermatocyte; ; lip; ; spermatid; ; triceps brachii muscle; ; superior frontal gyrus; ; retinal pigment epithelium; ; pituitary gland; ; temporal muscle; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; protein binding; molecular adaptor activity;
Cellular component	myofibril; cytoplasm; microtubule organizing center; cytoskeleton; centrosome; Golgi apparatus; nucleus; cortical microtubule plus-end;
Biological process	regulation of Golgi organization; astral microtubule organization; positive regulation of microtubule nucleation;
	Sources:Amigo / QuickGO
Orthologs
	9659
	83679
	ENSG00000178104
	ENSMUSG00000038170
	Q5VU43
	Q80YT7
NM_001002810; NM_001002811; NM_001002812; NM_001195260; NM_001195261;
	NM_001198832; NM_001198834; NM_014644; NM_022359; NM_001350520; NM_001350521; NM_001350522; NM_001350523; NM_001377392; NM_001377393
NM_001039376; NM_001110163; NM_001289701; NM_001289702; NM_031401;
	NM_177145; NM_178080
NP_001002810; NP_001002811; NP_001002812; NP_001182189; NP_001182190;
	NP_001185761; NP_001185763; NP_001337449; NP_001337450; NP_001337451; NP_001337452; NP_055459; NP_071754; NP_001364321; NP_001364322
	NP_001034465; NP_001276630; NP_001276631; NP_835181
	Wikidata
View/Edit Human	View/Edit Mouse

Myomegalin, also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2, is a protein that in humans is encoded by the PDE4DIP gene.^[5]^[6]^[7] It has roles in the formation of microtubules from the centrosome.^[8] Its name derives from the fact that it is highly expressed in units of tubular myofibrils known as sarcomeres and is a large protein, at 2,324 amino acids.^[9] It was first characterised in 2000.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038170 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, et al. (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, et al. (April 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal of Biological Chemistry. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. hdl:11573/1681344. PMID 11134006.
^ "Entrez Gene: PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)".
^ Roubin R, Acquaviva C, Chevrier V, Sedjaï F, Zyss D, Birnbaum D, Rosnet O (February 2013). "Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules". Biology Open. 2 (2): 238–50. doi:10.1242/bio.20123392. PMC 3575658. PMID 23430395.
^ ^a ^b Cite error: The named reference :1 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178104 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038170 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, et al. (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.

[pmid11134006-6] Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, et al. (April 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal of Biological Chemistry. 276 (14): 11189–98. doi:10.1074/jbc.M006546200. hdl:11573/1681344. PMID 11134006.

[entrez-7] "Entrez Gene: PDE4DIP phosphodiesterase 4D interacting protein (myomegalin)".

[:0-8] Roubin R, Acquaviva C, Chevrier V, Sedjaï F, Zyss D, Birnbaum D, Rosnet O (February 2013). "Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules". Biology Open. 2 (2): 238–50. doi:10.1242/bio.20123392. PMC 3575658. PMID 23430395.

[:1-9] Cite error: The named reference :1 was invoked but never defined (see the help page).

Myomegalin information

and 7 Related for: Myomegalin information

Myomegalin

Olduvai domain

CAMSAP2

NBPF

PDE4D

CDK5RAP2

SYNPO2