PDE4B information

PDE4B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F
Identifiers
Aliases	PDE4B, DPDE4, PDEIVB, phosphodiesterase 4B
External IDs	OMIM: 600127; MGI: 99557; HomoloGene: 1953; GeneCards: PDE4B; OMA:PDE4B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	66,374,579 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	102,464,456 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; cartilage tissue; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; superior vestibular nucleus; ; ventral tegmental area; ; external globus pallidus; ; middle temporal gyrus; ; pars reticulata; ; pons;
	Top expressed in
	left lung lobe; ; nucleus accumbens; ; olfactory tubercle; ; supraoptic nucleus; ; dorsal striatum; ; triceps brachii muscle; ; muscle of thigh; ; medial head of gastrocnemius muscle; ; temporal muscle; ; vastus lateralis muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; cAMP binding; gamma-tubulin binding; transmembrane transporter binding; phosphoric diester hydrolase activity; 3',5'-cyclic-AMP phosphodiesterase activity; protein binding;
Cellular component	voltage-gated calcium channel complex; gamma-tubulin complex; cell periphery; cytosol; postsynaptic density; dendritic spine; membrane; centrosome; Z disc; excitatory synapse; synaptic vesicle;
Biological process	regulation of high voltage-gated calcium channel activity; neutrophil homeostasis; regulation of cardiac muscle cell contraction; positive regulation of interferon-gamma production; signal transduction; cellular response to lipopolysaccharide; positive regulation of interleukin-2 production; leukocyte migration; negative regulation of relaxation of cardiac muscle; cellular response to epinephrine stimulus; T cell receptor signaling pathway; neutrophil chemotaxis; cAMP catabolic process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5142
	18578
	ENSG00000184588
	ENSMUSG00000028525
	Q07343
	n/a
NM_001037339; NM_001037340; NM_001037341; NM_001297440; NM_001297441;
	NM_001297442; NM_002600
NM_001177980; NM_001177981; NM_001177982; NM_001177983; NM_019840;
	NM_001374780
NP_001032416; NP_001032417; NP_001032418; NP_001284369; NP_001284370;
	NP_001284371; NP_002591; NP_001032418.1; NP_002591.2
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.^[5]

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)".
^ Swerdlow, Neal R. (2010-08-19). Behavioral Neurobiology of Schizophrenia and Its Treatment. Springer Science & Business Media. ISBN 9783642137174.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)".

[6] Swerdlow, Neal R. (2010-08-19). Behavioral Neurobiology of Schizophrenia and Its Treatment. Springer Science & Business Media. ISBN 9783642137174.

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