The p53 p63 p73 family is a family of tumor suppressor genes.[1][2]
This gene family codes the proteins:
p53
TP73L (also known as "p63")
p73
They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis.[3]
^Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G (May 2000). "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". Journal of Cell Science. 113 ( Pt 10) (10): 1661–1670. doi:10.1242/jcs.113.10.1661. PMID 10769197.
^Finch CE (2007). The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. pp. 350–. ISBN 978-0-12-373657-4. Retrieved 23 December 2010.
^Chen S, Moroi Y, Urabe K, Takeuchi S, Kido M, Hayashida S, et al. (August 2008). "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clinical and Experimental Dermatology. 33 (5): 634–640. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398. S2CID 19207163.
and 24 Related for: P53 p63 p73 family information
The p53p63p73family is a family of tumor suppressor genes. This gene family codes the proteins: p53 TP73L (also known as "p63") p73 They are sometimes...
"Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53family in vivo". The Journal of Biological Chemistry. 277 (35):...
p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is...
cyclin-CDK complexes. The p53 tumor-suppressor protein plays a crucial role at the G1/S checkpoint and the G2/M checkpoint. Activated p53 proteins result in...
suggest that p63 was the original member of the family from which p53 and p73 evolved. Tumor protein p63 is a member of the p53family of transcription...
hypoxia, tumor suppressor p53 overexpression may be associated with HIF1A-dependent pathway to initiate apoptosis. Moreover, p53-independent pathway may...
and p53 when DNA damage occurs, rendering p53 to associate more frequently with the E3-ubiquitin ligase HDM2 (also known as MDM2) and increasing p53 instability...
pro-apoptotic activity of p53 is restrained by the pRb pathway, such that pRb deficient tumor cells become sensitive to p53 mediated cell death. This...
"The DNA-binding domain mediates both nuclear and cytosolic functions of p53". Nature Structural & Molecular Biology. 21 (6): 535–543. doi:10.1038/nsmb...
injury after intracerebral hemorrhage. The glutathione S-transferase (GST) family includes cytosolic, mitochondrial, and microsomal enzymes that catalyze...
and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop". Molecular and Cellular Biology. 27 (1):...
Hif1alpha and COX-2, respectively. HoxA5 also upregulates the tumor suppressor p53 and Akt1 by downregulation of PTEN. Suppression of HoxA5 has been shown to...
Further, it was revealed that DNA damage-induced cell death in p53-deficient and p53-proficient cells was reduced when human FOXO1 is silenced by siRNA...
on bone marrow-derived GBM-infiltrating DCs. HMGB1 has to interact with p53. HMGB1 is a nuclear protein that binds to DNA and acts as an architectural...
humans, is encoded by the FOXP2 gene. FOXP2 is a member of the forkhead box family of transcription factors, proteins that regulate gene expression by binding...
level of p53 and p21, and exhibits accelerated cell proliferation. C-jun represses p53 transcription by binding to a variant AP-1 site in the p53 promoter...
"A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". The Journal of Biological Chemistry. 274 (6): 3700–4...
estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER...
1038/nature06947. PMID 18463634. S2CID 4429401. Qu J, Yi G, Zhou H (June 2019). "p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes"...
a critical tumor suppressor. Zbtb7 is also involved in the regulation of p53, another tumor suppressor gene. As an oncogene, Zbtb7 is overexpressed in...
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