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Ozogamicin information


Ozogamicin
Identifiers
IUPAC name
  • methyl(1R,4Z,8S,13E )-13-[2-[[2-[[[p-(3-carbamoylpropoxy)-α-methylbenzylidene]hydrazino]carbonyl]-1,1-dimethylethyl]dithio]ethylidene]-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-o-toluoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(N-ethylacetamido)-3-O-methyl-α-L-threo-pentopyranosyl]-β-D-glucopyranosyl]oxy]-1-hydroxy-11-oxobicyclo[7.3.1]trideca-4,9-diene-2,6-diyne-10-carbamate [1]: 5 
CAS Number
  • 400046-53-9
UNII
  • EDM24GA51F
CompTox Dashboard (EPA)
  • DTXSID001350185 Edit this at Wikidata
Chemical and physical data
FormulaC73H97IN6O25S3
Molar mass1681.68 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCN(C1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSC(C)(C)CC(=O)NN=C(C)C5=CC=C(C=C5)OCCCC(=O)N)NC(=O)OC)O)C)NOC6CC(C(C(O6)C)SC(=O)C7=C(C(=C(C(=C7OC)OC)OC8C(C(C(C(O8)C)O)OC)O)I)C)O)O)C(=O)C
InChI
  • InChI=1S/C73H97IN6O25S3/c1-15-80(41(7)81)45-35-98-52(32-49(45)92-10)103-65-60(87)57(79-105-53-31-46(82)67(40(6)99-53)107-68(89)54-36(2)56(74)63(66(95-13)62(54)93-11)104-69-61(88)64(94-12)59(86)39(5)101-69)38(4)100-70(65)102-48-21-18-16-17-19-28-73(91)33-47(83)58(76-71(90)96-14)55(48)44(73)27-30-106-108-72(8,9)34-51(85)78-77-37(3)42-23-25-43(26-24-42)97-29-20-22-50(75)84/h16-17,23-27,38-40,45-46,48-49,52-53,57,59-61,64-65,67,69-70,79,82,86-88,91H,15,20,22,29-35H2,1-14H3,(H2,75,84)(H,76,90)(H,78,85)/b17-16-,44-27+,77-37+/t38-,39+,40-,45+,46+,48+,49+,52+,53+,57-,59+,60+,61-,64-,65-,67-,69+,70+,73+/m1/s1
  • Key:HNMATTJJEPZZMM-BPKVFSPJSA-N

The term ozogamicin in the names of monoclonal antibodies or antibody-drug conjugates indicates that they are linked to a cytotoxic agent from the class of calicheamicins.[2]

  1. ^ "マイロターグ点滴静注用5mg インタビューフォーム" [Myrotarg 5mg for intravenous drip infusion interview form] (PDF). www.info.pmda.go.jp (in Japanese). Retrieved 2021-12-28.
  2. ^ Jabbour E, Paul S, Kantarjian H (July 2021). "The clinical development of antibody-drug conjugates - lessons from leukaemia". Nature Reviews. Clinical Oncology. 18 (7): 418–433. doi:10.1038/s41571-021-00484-2. PMID 33758376. S2CID 232329035.

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Inotuzumab ozogamicin

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Inotuzumab ozogamicin, sold under the brand name Besponsa, is an antibody-drug conjugate medication used to treat relapsed or refractory B-cell precursor...

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Gemtuzumab ozogamicin

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Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute...

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Ozogamicin

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The term ozogamicin in the names of monoclonal antibodies or antibody-drug conjugates indicates that they are linked to a cytotoxic agent from the class...

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CD33

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expression is known to be tied to TREM2. CD33 is the target of gemtuzumab ozogamicin (trade name: Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), an antibody-drug...

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Calicheamicin

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(AML). A second calicheamicin-linked monoclonal antibody, inotuzumab ozogamicin (marketed as Besponsa), an anti-CD22-directed antibody-drug conjugate...

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Chemotherapy

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systemic approaches. The first approved drug of this type was gemtuzumab ozogamicin (Mylotarg), released by Wyeth (now Pfizer). The drug was approved to treat...

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Acute promyelocytic leukemia

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the differentiating promyelocytes. The monoclonal antibody, gemtuzumab ozogamicin, has been used successfully as a treatment for APL, although it has been...

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Elranatamab

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Tositumomab), CD30 (Brentuximab), CD52 (Alemtuzumab) myeloid: CD33 (Gemtuzumab ozogamicin) Other Amivantamab Atezolizumab Avelumab Belantamab mafodotin Bermekimab...

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List of withdrawn drugs

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toxicity. Gatifloxacin 2006 US Increased risk of dysglycemia. Gemtuzumab ozogamicin (Mylotarg) 2010 US No improvement in clinical benefit; risk for death...

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ATC code L01

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Rituximab L01FA02 Ofatumumab L01FA03 Obinutuzumab L01FB01 Inotuzumab ozogamicin L01FB02 Moxetumomab pasudotox L01FC01 Daratumumab L01FC02 Isatuximab L01FD01...

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Monoclonal antibody

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cancer include: Alemtuzumab Bevacizumab Cetuximab Dostarlimab Gemtuzumab ozogamicin Ipilimumab Nivolumab Ofatumumab Panitumumab Pembrolizumab Ranibizumab...

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List of antileukemic drugs

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arabinoside Dasatinib Daunorubicin Decitabine Etoposide Fludarabine Gemtuzumab ozogamicin Idarubicin Imatinib mesylate Interferon-α Interleukin-2 Melphalan Methotrexate...

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Celltech

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Semprex-D, an antihistamine and decongestant Inotuzumab ozogamicin and gemtuzumab ozogamicin, both through Celltech's collaboration with Wyeth. Amongst...

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List of antineoplastic agents

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hypocalcaemia, osteonecrosis of the jaw and anaphylaxis. Gemtuzumab ozogamicin IV CD33 antibody that induces apoptosis of the tagged cell. Acute myeloid...

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Monoclonal antibody therapy

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hypercholesterolemia Refractory hypercholesterolemia 125522 Link gemtuzumab ozogamicin Mylotarg Wyeth 9/1/17 intravenous humanized, antibody-drug conjugate CD33...

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Mosunetuzumab

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Tositumomab), CD30 (Brentuximab), CD52 (Alemtuzumab) myeloid: CD33 (Gemtuzumab ozogamicin) Other Amivantamab Atezolizumab Avelumab Belantamab mafodotin Bermekimab...

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List of human clusters of differentiation

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Anti-CD22 monoclonal antibodies have been developed, notably inotuzumab ozogamicin, approved by the FDA in 2017 for relapsed and refractory CD22-positive...

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List of drugs granted breakthrough therapy designation

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Cytarabine/daunorubicin Celator Pharmaceuticals acute myeloid leukemia Inotuzumab ozogamicin Wyeth Pharmaceuticals B-cell precursor acute lymphoblastic leukemia Deutetrabenazine...

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Follicular lymphoma

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monoclonal antibodies such as rituximab, obinutuzumab, galiximab, inotuzumab ozogamicin, or epratuzumab and immunomodulators such as lenalidomide and interferon...

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Fine chemical

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Fomivirsen and, more recently, Pfizer's (formerly Wyeth) Mylotarg (gemtuzumab ozogamicin). Examples of ADCs in phase III of development are Abbott's / Isis's Alicaforsen...

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Naptumomab estafenatox

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Farletuzumab§ Ficlatuzumab§ Flotetuzumab§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab§ Inotuzumab ozogamicin Labetuzumab§ Lifastuzumab vedotin§ Lintuzumab§...

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Bioconjugation

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Antibody-drug conjugates such as Brentuximab vedotin and Gemtuzumab ozogamicin are examples falling into this category. Protein-protein conjugations...

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CD22

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PMC 6325303. PMID 30622147. Research Cf (2019-02-09). "FDA approves inotuzumab ozogamicin for relapsed or refractory B-cell precursor ALL". FDA. Poe JC, Fujimoto...

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Minretumomab

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Farletuzumab§ Ficlatuzumab§ Flotetuzumab§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab§ Inotuzumab ozogamicin Labetuzumab§ Lifastuzumab vedotin§ Lintuzumab§...

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gefitinib – geldanamycin analog – GEM 231 – gemcitabine – gemtuzumab ozogamicin – gene expression profiling – gene therapy – gene transfer – gene-modified...

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