Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute myeloid leukemia.[6][8][9]
The most common side effects include infection, febrile neutropenia, decreased appetite, hyperglycemia, mucositis, hypoxia, hemorrhage, increased transaminase, diarrhea, nausea, and hypotension.[10] However, the addition of gemtuzumab ozogamicin to standard chemotherapy regimens does not increase infection rates. [11]
^ ab"Mylotarg Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 17 April 2020. Retrieved 17 August 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^AusPAR: Gemtuzumab ozogamicin. Therapeutic Goods Administration (TGA) (Report). October 2020.
^"Summary Basis of Decision (SBD) for Mylotarg". Health Canada. 23 October 2014. Retrieved 29 May 2022.
^"Mylotarg 5mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 29 October 2019. Retrieved 17 August 2020.
^ abCite error: The named reference Mylotarg FDA label was invoked but never defined (see the help page).
^Cite error: The named reference Mylotarg EPAR was invoked but never defined (see the help page).
^Cite error: The named reference FDA PR was invoked but never defined (see the help page).
^"FDA Approves Gemtuzumab Ozogamicin for CD33-positive AML". U.S. Food and Drug Administration (FDA) (Press release). 1 September 2017. Retrieved 6 September 2017. This article incorporates text from this source, which is in the public domain.
^Cite error: The named reference FDA gemtuzumab ozogamicin indication change was invoked but never defined (see the help page).
^Kyriakidis I, Mantadakis E, Stiakaki E, Groll AH, Tragiannidis A (October 2022). "Infectious Complications of Targeted Therapies in Children with Leukemias and Lymphomas". Cancers. 14 (20): 5022. doi:10.3390/cancers14205022. PMC 9599435. PMID 36291806.
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Gemtuzumabozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute...
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traditional systemic approaches. The first approved drug of this type was gemtuzumabozogamicin (Mylotarg), released by Wyeth (now Pfizer). The drug was approved...
Liver toxicity. Gatifloxacin 2006 US Increased risk of dysglycemia. Gemtuzumabozogamicin (Mylotarg) 2010 US No improvement in clinical benefit; risk for...
retention, hypocalcaemia, osteonecrosis of the jaw and anaphylaxis. Gemtuzumabozogamicin IV CD33 antibody that induces apoptosis of the tagged cell. Acute...
protein. Antibody-drug conjugates such as Brentuximab vedotin and Gemtuzumabozogamicin are examples falling into this category. Protein-protein conjugations...
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This article incorporates text from this source, which is in the public domain.
