Major active metabolite of ketamine
Norketamine ATC code Legal status
CA : Schedule I
UK : Class B
2-Amino-2-(2-chlorophenyl)cyclohexan-1-one
CAS Number 35211-10-0 79499-59-5 (HCl)PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) DTXSID40891434 Formula C 12 H 14 Cl N O Molar mass 223.70 g·mol−1 3D model (JSmol)
C1CCC(C(=O)C1)(C2=CC=CC=C2Cl)N
InChI=1S/C12H14ClNO/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15/h1-2,5-6H,3-4,7-8,14H2
Key:BEQZHFIKTBVCAU-UHFFFAOYSA-N
Norketamine , or N -desmethylketamine , is the major active metabolite of ketamine, which is formed mainly by CYP3A4.[1] [2] Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist,[1] [3] but is about 3–5 times less potent as an anesthetic in comparison.[2] [4]
^ a b Adams AP, Cashman JN, Grounds RM (12 January 2002). Recent Advances in Anaesthesia and Intensive Care . Cambridge University Press. pp. 42–. ISBN 978-1-84110-117-0 .
^ a b Barceloux DG (3 February 2012). Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants . John Wiley & Sons. pp. 112–. ISBN 978-1-118-10605-1 .
^ Smith HS (21 December 2008). Current Therapy in Pain . Elsevier Health Sciences. pp. 482–. ISBN 978-1-4377-1117-2 .
^ Stanley TH, Schafer PG (6 December 2012). Pediatric and Obstetrical Anesthesia: Papers presented at the 40th Annual Postgraduate Course in Anesthesiology, February 1995 . Springer Science & Business Media. pp. 372–. ISBN 978-94-011-0319-0 .
Last Update: 2024-01-07T06:30:52Z
Norketamine , or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine ...
Word Count : 1026
Last Update: 2023-05-29T16:52:52Z
antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine , another metabolite of ketamine. As of late 2019, (2R,6R)-HNK is in clinical...
Word Count : 1404
Last Update: 2023-12-07T19:10:17Z
metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine . Though originally considered to be inactive, DHNK has been found to...
Word Count : 470
Last Update: 2024-05-15T06:45:51Z
CYP3A4. As a result, norketamine plasma levels are several-fold higher than ketamine following oral administration, and norketamine may play a role in anesthetic...
Word Count : 11403
Last Update: 2024-05-22T20:02:31Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 15730
Last Update: 2024-05-15T19:19:35Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 16528
Last Update: 2024-05-11T15:01:13Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 10920
Last Update: 2024-04-21T16:20:18Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 11931
Last Update: 2024-05-17T21:49:12Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 13643
Last Update: 2024-05-22T07:56:50Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 11356
Last Update: 2024-05-16T06:53:44Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 15006
Last Update: 2024-05-05T19:23:47Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 11150
Last Update: 2024-05-08T15:57:02Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 10524
Last Update: 2024-05-18T04:23:54Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 5373
Last Update: 2024-05-08T14:03:23Z
Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD-137889 Pethidine (meperidine) Phencyclamine Phencyclidine...
Word Count : 3236
Last Update: 2024-05-22T07:13:39Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 14638
Last Update: 2024-05-15T08:27:53Z
Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD-137889 Pethidine (meperidine) Phencyclamine Phencyclidine...
Word Count : 16879
Last Update: 2024-05-18T20:28:41Z
Metocurine Mivacurium Morphanol (racemorphan) Neramexane Nitrous oxide Norketamine Pancuronium bromide Pempidine Pentamine Pentolinium Phencyclidine Pipecuronium...
Word Count : 7608
Last Update: 2024-01-22T04:39:46Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 3073
Last Update: 2024-05-16T08:40:22Z
Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD-137889 Pethidine (meperidine) Phencyclamine Phencyclidine...
Word Count : 7673
Last Update: 2024-04-15T07:04:24Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 4053
Last Update: 2024-05-12T02:56:59Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 19665
Last Update: 2024-04-09T21:12:59Z
esketamine and their respective metabolites at the α7-nicotinic receptor, as norketamine and hydroxynorketamine are potent antagonists of this receptor and markers...
Word Count : 1236
Last Update: 2024-04-28T13:53:01Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 2289
Last Update: 2024-03-27T19:25:47Z
Metocurine Mivacurium Morphanol (racemorphan) Neramexane Nitrous oxide Norketamine Pancuronium bromide Pempidine Pentamine Pentolinium Phencyclidine Pipecuronium...
Word Count : 6134
Last Update: 2024-05-20T19:19:32Z
Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine Norketamine Nufenoxole Octreotide Oliceridine Oxycodegol OM-3-MNZ Oripavine Oxycodone...
Word Count : 8115
Last Update: 2024-05-20T22:08:16Z
((S)-ketamine) Ketamine Methoxetamine Methoxmetamine Methoxyketamine MXiPr Norketamine Tiletamine PCP-related 2'-Oxo-PCE 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP...
Word Count : 8405