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Medical condition
Neuromyotonia
Other names
Isaacs syndrome, Isaacs-Mertens syndrome
Specialty
Neurology, neuromuscular medicine
Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. NMT along with Morvan's syndrome are the most severe types in the Peripheral Nerve Hyperexciteability spectrum. Example of two more common and less severe syndromes in the spectrum are cramp fasciculation syndrome and benign fasciculation syndrome.[1] NMT can have both hereditary and acquired (non-inherited) forms. The prevalence of NMT is unknown.[2]
^Noto, Y. I.; Simon, N. G.; Selby, A.; Garg, N.; Shibuya, K.; Shahrizaila, N.; Huynh, W.; Matamala, J. M.; Dharmadasa, T.; Park, S. B.; Vucic, S.; Kiernan, M. C. (2018). "PNH study". Clinical Neurophysiology. 129 (5): 974–980. doi:10.1016/j.clinph.2018.01.061. PMID 29554580. S2CID 4522709.
^"Isaac syndrome". OrphaNet. 2013. Retrieved 30 November 2015.
Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action...
stiffness similar to those seen in neuromyotonia (another related condition). Patients with CFS, like those with neuromyotonia, may also experience paresthesias...
found to occur due to gene mutations other than SCN4A.[citation needed] Neuromyotonia (also known as Isaac's Syndrome or NMT) causes peripheral nerve hyperexcitability...
Autosomal recessive axonal neuropathy with neuromyotonia, also known as Gamstorp-Wohlfart syndrome, is a rare hereditary disorder which is characterized...
[citation needed] Myokymia in otherwise unrelated body parts may occur in neuromyotonia. Frequent contributing factors include: too much caffeine, high levels...
29) The diseases that act on the presynaptic membrane are autoimmune neuromyotonia, Lambert–Eaton syndrome, congenital myasthenia gravis and botulism.(reference...
antibodies that target CASPR2 (to treat nerve hyperexcitability and neuromyotonia). "Paraneoplastic Syndromes". National Institute of Neurological Disorders...
researcher and academic, known for his research on nerve cells and neuromyotonia. He was a vice chancellor of Rajasthan University of Health Sciences...
azathioprine in the event that 3,4-diaminopyridine does not aid in treatment. Neuromyotonia (NMT), otherwise known as Isaac's syndrome, is unlike many other diseases...
larger spectrum of disease that also incorporates acquired auto-immune neuromyotonia. Other serious diseases that must be distinguished include motor neuron...
eventually death, usually related to respiratory weakness. (G71.1) Myotonia Neuromyotonia (G71.2) The congenital myopathies do not show evidence for either a...
(affecting only one side of the body) G25.85 Myokymia, facial G51.4 Neuromyotonia (Isaacs Syndrome) 359.29 G71.19 Opsoclonus 379.59 H57 Rheumatic chorea...
mobile phone system Neurologic Music Therapy Neural machine translation Neuromyotonia, a form of peripheral nerve hyperexcitability Network management protocols...
antibodies (anti-VGKC) date back to 2001 and described patients with neuromyotonia, Morvan's syndrome and limbic encephalitis. Other rare phenotypes included...
with muscle stiffness and spontaneous muscle twitching, an autoimmune neuromyotonia or Morvan syndrome diagnosis may be considered. Chronic and progressive...
episodic ataxia with myokymia (EAM), hereditary paroxysmal ataxia with neuromyotonia and Isaacs-Mertens syndrome. Onset of EA1 occurs during early childhood...
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