Cramp fasciculation syndrome (CFS) is a rare[1] peripheral nerve hyperexcitability disorder. It is more severe than the related (and common) disorder known as benign fasciculation syndrome; it causes fasciculations, cramps, pain, fatigue, and muscle stiffness similar to those seen in neuromyotonia (another related condition).[2] Patients with CFS, like those with neuromyotonia, may also experience paresthesias.[3]
Most cases of cramp fasciculation syndrome are idiopathic.[4]
Cramp fasciculation syndrome is diagnosed by clinical examination and electromyography (EMG).[5] Fasciculation is the only abnormality[6] (if any)[7] seen with EMG.
Cramp fasciculation syndrome is a chronic condition.[8] Treatment options include anti-seizure medications such as carbamazepine, immunosuppressive drugs and plasmapheresis.[4]
^Jansen, P. H. P.; Dijck, J. A. A. M.; Verbeek, A. L. M.; Durian, F. W.; Joosten, E. M. G. (1991). "Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population". European Archives of Psychiatry and Clinical Neuroscience. 241 (2): 102–4. doi:10.1007/BF02191150. PMID 1834178. S2CID 30203831.
^Ropper, Allan H.; Brown, Robert H. (2005). "Disorders of Muscle Characterized by Cramp, Spasm, Pain, and Localized Masses". Adams and Victor's Principles of Neurology (8th ed.). New York: McGraw-Hill. pp. 1277–8. ISBN 978-0-07-141620-7.
^Hart, Ian K.; Maddison, Paul; Newsom‐Davis, John; Vincent, Angela; Mills, Kerry R. (2002). "Phenotypic variants of autoimmune peripheral nerve hyperexcitability". Brain. 125 (8): 1887–95. doi:10.1093/brain/awf178. PMID 12135978.
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