Global InformationNeuroglobin information
| Neuroglobin | |||||||
|---|---|---|---|---|---|---|---|
 Model of murine neuroglobin from PDB: 1Q1F | |||||||
| Identifiers | |||||||
| Symbol | NGB | ||||||
| NCBI gene | 58157 | ||||||
| HGNC | 6553 | ||||||
| OMIM | 605304 | ||||||
| UniProt | Q9NPG2 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q24 | ||||||
| |||||||
Neuroglobin is a member of the vertebrate globin family involved in cellular oxygen homeostasis and reactive oxygen/nitrogen scavenging. It is an intracellular hemoprotein expressed in the central and peripheral nervous system, cerebrospinal fluid, retina and endocrine tissues. Neuroglobin is a monomer that reversibly binds oxygen with an affinity higher than that of hemoglobin. It also increases oxygen availability to brain tissue and provides protection under hypoxic or ischemic conditions, potentially limiting brain damage. Neuroglobin were in the past found only in vertebrate neurons, but recently in 2013, were found in the neurons of unrelated protostomes, like photosynthetic acoel as well as radiata such as jellyfish. In addition to neurons, neuroglobin is present in astrocytes in certain pathologies of the rodent brain[1][2] and in the physiological seal brain.[3] This is thought to be due to convergent evolution.[4] It is of ancient evolutionary origin, and is homologous to nerve globins of invertebrates. Recent research confirmed the presence of human neuroglobin protein in cerebrospinal fluid (CSF).[5]
Neuroglobin was first identified by Thorsten Burmester et al. in 2000.[6]
The 3D structure of human neuroglobin was determined in 2003.[7] The next year, murine neuroglobin was determined at a higher resolution.[8]
A practical treatment for carbon monoxide poisoning based on binding of CO by neuroglobin (Ngb) with a mutated distal histidine (H64Q) appears to be possible.[9]
- ^ DellaValle B, Hempel C, Kurtzhals JA, Penkowa M (August 2010). "In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis". Glia. 58 (10): 1220–7. doi:10.1002/glia.21002. PMID 20544857. S2CID 8563830.
- ^ De Marinis E, Acaz-Fonseca E, Arevalo MA, et al. (March 2013). "17β-Oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor β-mediated neuroglobin up-regulation" (PDF). Journal of Neuroendocrinology. 25 (3): 260–70. doi:10.1111/jne.12007. PMID 23190172. S2CID 12425782.
- ^ Mitz SA, Reuss S, Folkow LP, et al. (October 2009). "When the brain goes diving: glial oxidative metabolism may confer hypoxia tolerance to the seal brain". Neuroscience. 163 (2): 552–60. doi:10.1016/j.neuroscience.2009.06.058. PMID 19576963. S2CID 207246404.
- ^ science.gov, Neuroglobins, Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity by Lechauve, Christophe; Jager, Muriel; Laguerre, Laurent; Kiger, Laurent; Correc, Gaelle; Leroux, Cedric; Vinogradov, Serge; Czjzek, Mirjam; Marden, Michael C.; Bail
- ^ Casado B, Pannell LK, Whalen G, Clauw DJ, Baraniuk JN (February 2005). "Human neuroglobin protein in cerebrospinal fluid" (PDF). Proteome Science. 3 (1): 2. doi:10.1186/1477-5956-3-2. PMC 554085. PMID 15730566.
- ^ Burmester T, Weich B, Reinhardt S, Hankeln T (September 2000). "A vertebrate globin expressed in the brain". Nature. 407 (6803): 520–3. Bibcode:2000Natur.407..520B. doi:10.1038/35035093. PMID 11029004. S2CID 4337897.
- ^ Alessandra Pesce; Sylvia Dewilde; Marco Nardini; Luc Moens; Paolo Ascenzi; Thomas Hankeln; Thorsten Burmester & Martino Bolognes (2003). "Human Brain Neuroglobin Structure Reveals a Distinct Mode of Controlling Oxygen Affinity". Structure. 11 (9): 1087–1095. doi:10.1016/S0969-2126(03)00166-7. hdl:10067/455310151162165141. PMID 12962627.
- ^ Beatrice Vallone; Karin Nienhaus; Maurizio Brunori; G. Ulrich Nienhaus (2004). "The structure of murine neuroglobin: Novel pathways for ligand migration and binding". Proteins: Structure, Function, and Bioinformatics. 56 (1): 85–92. doi:10.1002/prot.20113. PMID 15162488. S2CID 29990150.
- ^ Rydzewski, J; Nowak, W (2018). "Photoinduced transport in an H64Q neuroglobin antidote for carbon monoxide poisoning". The Journal of Chemical Physics. 148 (11): 115101. Bibcode:2018JChPh.148k5101R. doi:10.1063/1.5013659. PMID 29566507.