Cytoglobin information

CYGB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UMO, 1URV, 1URY, 1UT0, 1UX9, 1V5H, 2DC3, 3AG0, 4B3W
Identifiers
Aliases	CYGB, HGB, STAP, cytoglobin
External IDs	OMIM: 608759 MGI: 2149481 HomoloGene: 12706 GeneCards: CYGB
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,551,175 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,545,139 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastric mucosa; ; canal of the cervix; ; tibial nerve; ; urinary bladder; ; right coronary artery; ; left coronary artery; ; left uterine tube;
	Top expressed in
	interventricular septum; ; aortic valve; ; ascending aorta; ; habenula; ; dorsal tegmental nucleus; ; ankle; ; lateral hypothalamus; ; medial vestibular nucleus; ; superior colliculus; ; cardiac muscles;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fatty acid peroxidase activity; metal ion binding; heme binding; peroxidase activity; catalase activity; nitric oxide dioxygenase activity; oxygen binding; oxygen carrier activity; iron ion binding; protein binding;
Cellular component	cytoplasm; cytosol; neuron projection; neuronal cell body; nuclear speck;
Biological process	response to hypoxia; response to oxidative stress; negative regulation of hepatic stellate cell activation; negative regulation of collagen biosynthetic process; fatty acid oxidation; regulation of nitric-oxide synthase activity; negative regulation of fibroblast migration; cellular oxidant detoxification; oxygen transport;
	Sources:Amigo / QuickGO
Orthologs
	114757
	114886
	ENSG00000161544
	ENSMUSG00000020810
	Q8WWM9
	Q9CX80
	NM_134268
	NM_030206
	NP_599030
	NP_084482
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoglobin is the protein product of CYGB, a human and mammalian gene.^[5]

Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001^[6] and named cytoglobin in 2002.^[7] It is thought to protect against hypoxia. The predicted function of cytoglobin is the transfer of oxygen from arterial blood to the brain.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161544 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020810 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells". The Journal of Biological Chemistry. 276 (27): 25318–23. doi:10.1074/jbc.M102630200. PMID 11320098.
^ Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues". Molecular Biology and Evolution. 19 (4): 416–21. doi:10.1093/oxfordjournals.molbev.a004096. PMID 11919282.
^ "Why Diving Marine Mammals Resist Brain Damage from Low Oxygen". ScienceDaily. 20 December 2007.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161544 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020810 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[6] Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells". The Journal of Biological Chemistry. 276 (27): 25318–23. doi:10.1074/jbc.M102630200. PMID 11320098.

[7] Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues". Molecular Biology and Evolution. 19 (4): 416–21. doi:10.1093/oxfordjournals.molbev.a004096. PMID 11919282.

[sciencedaily-8] "Why Diving Marine Mammals Resist Brain Damage from Low Oxygen". ScienceDaily. 20 December 2007.

Cytoglobin information

and 12 Related for: Cytoglobin information

Cytoglobin

Globin

Hepatic stellate cell

Diving reflex

Myoglobin

CYGB

Hemoprotein

Nitric oxide dioxygenase

P16

List of examples of convergent evolution

Neuroglobin

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