Form of treatment for genetic disorders and other illnesses
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA.[1] Several ASOs have been approved in the United States, the European Union, and elsewhere.
^Morcos PA (June 2007). "Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos". Biochemical and Biophysical Research Communications. 358 (2): 521–7. doi:10.1016/j.bbrc.2007.04.172. PMID 17493584.
Antisensetherapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA...
properties to the oligonucleotides and make them a key element in antisensetherapy. Oligonucleotides are chemically synthesized using building blocks...
function would provide an alternative to traditional antibiotic therapies. Antisensetherapy is being researched to treat a subset of mutations which have...
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded...
Pelacarsen is an antisensetherapy that is designed to reduce Lipoprotein(a) concentrations in people with high levels of the lipoprotein and who are...
head of research of GlaxoSmithKline, with a goal to commercialize antisensetherapy. In 1992, the company received its first approval by the Food and...
known as precise, efficient, stable and better than antisensetherapy for gene suppression. Antisense RNA produced intracellularly by an expression vector...
Olpasiran (AMG890) is an experimental antisensetherapy designed to lower the level of lipoprotein(a), which is believed to be a causal factor in the...
phosphate moiety is replaced by sulfur. These compounds are the basis of antisensetherapy, e.g., the drugs fomivirsen (Vitravene), Oblimersen, Alicaforsen,...
address the root cause are currently available including gene therapy (Elevidys), and antisense drugs (Ataluren, Eteplirsen etc.). Other medications used...
be used to treat about 14% of DMD cases. Eteplirsen is a form of antisensetherapy. Eteplirsen was developed by Steve Wilton, Sue Fletcher and colleagues...
molecular genetic-based methods of inhibiting telomerase, such as antisensetherapy and RNA interference. hTERT peptide fragments have been shown to induce...
reversed MECP2 Duplication Syndrome in adult symptomatic mice using antisensetherapy. Mice treated with an experimental ASO administered through the central...
other antisense antivirals are in development. An antisense structural type that has proven especially valuable in research is morpholino antisense. Morpholino...
exons to be skipped could be used to treat up to 50% of DMD patients. Antisensetherapy Wahl M (1 October 2011). "Exon Skipping in DMD: What Is It and Whom...
the phosphate moiety is replaced by sulfur. They are the basis of antisensetherapy, e.g., the drugs fomivirsen (Vitravene), oblimersen, alicaforsen,...
to target specific genetic code sequences – that is, antisensetherapy, a form of gene therapy. According to Riordan, he had always wanted to use the...
as immunoglobulin therapy, and experimental biology-based approaches such as phage therapy, fecal microbiota transplants, antisense RNA-based treatments...
Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide...
recent years in molecular biology procedures, diagnostic assays, and antisensetherapies. Due to their higher binding strength, it is not necessary to design...
2007). "A review of antisense therapeutic interventions for molecular biological targets in asthma". Biologics: Targets and Therapy. 1 (3): 271–83. PMC 2721314...
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