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The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.[5] Multiple alternatively spliced transcript variants have been described for this gene.[5] It is Gi-coupled, reducing intracellular levels of cAMP.
^ abcGRCh38: Ensembl release 89: ENSG00000181072 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045613 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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influences on the neuromuscular junction. Drugs that act on muscarinicacetylcholinereceptors, such as atropine, can be poisonous in large quantities, but...
anticholinergic agent that blocks the activity of the muscarinic acetylcholinereceptor. The muscarinicreceptor is a protein involved in the transmission of signals...
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concentrations up to 1.6%. Muscarine is a selective agonist of the muscarinicacetylcholinereceptors. The name muscarine derives from that of Amanita muscaria...
30 μM for the muscarinicacetylcholinereceptor using rat brain tissue while levchlorphenamine had a Ki value of 40 to 50 μM for this receptor, indicating...
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ligands have unique receptors. Some examples include: metabotropic glutamate receptors, muscarinicacetylcholinereceptors, GABAB receptors. The G protein-coupled...
central muscarinicacetylcholinereceptors. Scopolamine acts as a nonspecific muscarinic antagonist at all four (M1, M2, M3, and M4) receptor sites. In...
hM4Di, derived from the M4 muscarinicreceptor that couples with the Gi protein. Another Gi coupled human muscarinicreceptor, M2, was also mutated to obtain...
main types of muscarinicreceptors: The M1 muscarinicreceptors (CHRM1) are located in the neural system. The M2muscarinicreceptors (CHRM2) are located...
compound contained a piperazine scaffold and was a potent muscarinicacetylcholinereceptor (M2) antagonist with modest CCR5 activity. The changes that...
the neurotransmitter acetylcholine (ACh) at synapses with cardiac muscle cells. Acetylcholine then binds to M2muscarinicreceptors, causing the decrease...
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