Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Moronic acid (3-oxoolean-18-en-28-oic acid) is a natural triterpene.[1][2] Moronic acid can be extracted from Rhus javanica, a sumac plant traditionally believed to hold medicinal applications.[2] The molecule has also been extracted from mistletoe (Phoradendron reichenbachianum).[3]
Bevirimat, a derivative of the related triterpenoid betulinic acid, is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles in vitro than bevirimat.[4] A particular moronic acid derivative showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4-3, 0.021 μM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 μM against FHR-2 (an HIV strain resistant to (bevirimat). This derivative has become a new lead for clinical trials and is also active against herpes simplex virus 1.[4]
^ abKurokawa, Masahiko; Basnet, Purusotam; Ohsugi, Mizue; Hozumi, Toyoharu; Kadota, Shigetoshi; Namba, Tsuneo; Kawana, Takashi; Shiraki, Kimiyasu (1999). "Anti-Herpes Simplex Virus Activity of Moronic Acid Purified from Rhus javanica In Vitro and In Vivo". The Journal of Pharmacology and Experimental Therapeutics. 289 (1): 72–8. PMID 10086989.
^Rios, María Yolanda; Salinas, David; Villarreal, María Luisa (2001). "Cytotoxic Activity of Moronic Acid and Identification of the New Triterpene 3,4-seco-Olean-18-ene-3,28-dioic Acid from Phoradendron reichenbachianum". Planta Medica. 67 (5): 443–6. doi:10.1055/s-2001-15823. PMID 11488459.
Moronicacid (3-oxoolean-18-en-28-oic acid) is a natural triterpene. Moronicacid can be extracted from Rhus javanica, a sumac plant traditionally believed...
formosanum), chaga (Inonotus obliquus), and many other Syzygium species. Moronicacid Rhus javanica (a sumac), mistletoe Cafestol Coffea arabica in unfiltered...
derivatives, such as experimental antitumor agents. Betulinic acidMoronicacid Oleanolic acid CID 64945 from PubChem Constituents of Mirabilis jalapa. Siddiqui...
as the (R)-enantiomer, but racemizes at 300 °C. When warmed with mineral acid, limonene isomerizes to the conjugated diene α-terpinene (which can also...
particular note among these are sugar acids such as glucuronic acid and galacturonic acid, which are oxidized forms of glucose and galactose. Cardenolide...
TA-65 2.2-fold, and maslinic acid 2-fold. Ursolic acid Betulinic acidMoronicacid Momordin (saponin), a glycoside of oleanolic acid List of phytochemicals...
development of cancer was published. Moronicacid, a natural triterpene Traumatic acid, a monounsaturated dicarboxylic acid naturally occurring in plants Some...
is similar, as are the enzymes involved. Synthesis begins with mevalonic acid, which is converted into dimethylallyl pyrophosphate. This is then condensed...
PMID 19742422. Liu, Jie (December 1995). "Pharmacology of oleanolic acid and ursolic acid". Journal of Ethnopharmacology. 49 (2): 57–68. doi:10.1016/0378-8741(95)90032-2...
betanin, the simplest betacyan. In addition, betalamic acid reacts spontaneously with various amino acids or amines to form yellow-orange colored betaxanthins...
categories, such as carotenoids and polyphenols, which include phenolic acids, flavonoids, stilbenes or lignans. Flavonoids can be further divided into...
the branched-chain fatty acid pathway. To produce capsaicin, 8-methyl-6-nonenoyl-CoA is produced by the branched-chain fatty acid pathway and condensed with...
pyrophosphate, which is formed from acetyl-CoA via the intermediacy of mevalonic acid in the HMG-CoA reductase pathway. An alternative, unrelated biosynthesis...
types of cell signaling. They are able to signal the production of abscisic acid, which regulates plant growth, seed dormancy, embryo maturation and germination...
resist polymerization (low ceiling temperatures) but are susceptible to acid-induced carbocation formation. Selected terpenes Limonene, a monoterpene...
absorption A slowing of bile acid absorption in the ileum so bile acids escape through to the cecum Altered or increased bile acid metabolism in the cecum...
plants and structurally diverse. Polyphenols include flavonoids, tannic acid, and ellagitannin, some of which have been used historically as dyes and...
DMAPP and IPP. In the mevalonate pathway DMAPP is synthesised from mevalonic acid. In contrast, DMAPP is synthesised from HMBPP in the MEP pathway. At present...
2013. Retrieved 4 November 2013. Chester, DO (1979). "Three New Aliphatic Acids from Lichens of Genus Parmelia (Subgenus Xanthoparmelia )". Australian Journal...
either a Diels-Alder reaction or an intramolecular Michael addition. Loganic acid is an iridoid substrate converted to strictosidine which reacts with tryptamine...
sources are serum proteins, lectins and antibodies. Inorganic sources are moronicacid, metal chelates and triazine dyes. A third method, expanded bed absorption...
alcohol. It is oxidised to menthone by oxidising agents such as chromic acid, dichromate, or by calcium hypochlorite, in a green chemistry route. Under...
stir in some type of acid, which allows the newly harvested latex to mix with the previously coagulated material. The rubber/acid mixture is what gives...
despite test tube studies repeatedly showing anti-malarial activity. Moronicacid, another compound found in the plant, shows also potential anti-HIV activity...
principal male sex hormone and an anabolic steroid Cholic acid, a bile acid, showing the carboxylic acid and additional hydroxyl groups often present Dexamethasone...
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