negative regulation of interleukin-1 beta production
negative regulation of insulin secretion
regulation of synapse assembly
regulation of hindgut contraction
decidualization
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of fatty acid metabolic process
hormone-mediated signaling pathway
positive regulation of multicellular organism growth
cellular response to insulin stimulus
response to food
response to hormone
actin polymerization or depolymerization
negative regulation of inflammatory response
signal transduction
positive regulation of appetite
growth hormone secretion
adult feeding behavior
response to growth hormone
positive regulation of eating behavior
spermatogenesis
female pregnancy
learning or memory
negative regulation of norepinephrine secretion
negative regulation of appetite
response to follicle-stimulating hormone
response to estradiol
ghrelin secretion
regulation of transmission of nerve impulse
regulation of growth hormone secretion
cellular response to lipopolysaccharide
response to dexamethasone
negative regulation of locomotion involved in locomotory behavior
cellular response to thyroid hormone stimulus
positive regulation of sprouting angiogenesis
response to monosodium glutamate
regulation of gastric motility
positive regulation of vascular endothelial cell proliferation
cellular response to insulin-like growth factor stimulus
negative regulation of macrophage apoptotic process
positive regulation of growth
regulation of feeding behavior
positive regulation of small intestinal transit
positive regulation of small intestine smooth muscle contraction
G protein-coupled receptor signaling pathway
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
postsynaptic modulation of chemical synaptic transmission
regulation of postsynapse organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2693
208188
Ensembl
ENSG00000121853
ENSMUSG00000051136
UniProt
Q92847
Q99P50
RefSeq (mRNA)
NM_198407 NM_004122
NM_177330
RefSeq (protein)
NP_004113 NP_940799
NP_796304
Location (UCSC)
Chr 3: 172.44 – 172.45 Mb
Chr 3: 27.43 – 27.43 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone".[5][6] The role of GHS-R is thought to be in regulating energy homeostasis and body weight.[7] In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra.[8] Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000121853 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000051136 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, et al. (December 2005). "International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function". Pharmacological Reviews. 57 (4): 541–546. doi:10.1124/pr.57.4.1. PMID 16382107. S2CID 11254096.
^Pradhan G, Samson SL, Sun Y (November 2013). "Ghrelin: much more than a hunger hormone". Current Opinion in Clinical Nutrition and Metabolic Care. 16 (6): 619–624. doi:10.1097/mco.0b013e328365b9be. PMC 4049314. PMID 24100676.
^Pazos Y, Casanueva FF, Camiña JP (2008). "Basic aspects of ghrelin action". Ghrelin. Vitamins & Hormones. Vol. 77. pp. 89–119. doi:10.1016/S0083-6729(06)77005-4. ISBN 9780123736857. PMID 17983854.
^Andrews ZB (January 2011). "The extra-hypothalamic actions of ghrelin on neuronal function". Trends in Neurosciences. 34 (1): 31–40. doi:10.1016/j.tins.2010.10.001. PMID 21035199. S2CID 42200775.
^Yin Y, Li Y, Zhang W (March 2014). "The growth hormone secretagogue receptor: its intracellular signaling and regulation". International Journal of Molecular Sciences. 15 (3): 4837–4855. doi:10.3390/ijms15034837. PMC 3975427. PMID 24651458.
and 23 Related for: Growth hormone secretagogue receptor information
Growthhormonesecretagoguereceptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growthhormonesecretagogues (GHSs)...
induce the secretion) of growth hormone (GH). They include agonists of the ghrelin/growthhormonesecretagoguereceptor (GHSR), such as ghrelin (lenomorelin)...
ghrelin receptor (called growthhormonesecretagogue type 1A receptor or GHS-R) was determined in 1999. The hormone name is based on its role as a growth hormone-releasing...
hormone receptor (GHRHR) Ghrelin through binding to growthhormonesecretagoguereceptors (GHSR) Sex hormones Increased androgen secretion during puberty (in...
peptide selective agonist of the ghrelin/growthhormonesecretagoguereceptor (GHS) and a growthhormonesecretagogue. It is a pentapeptide with the amino...
D-Ala-D-(β-naphthyl)-Ala-Trp-D-Phe-Lys-NH2. It acts as a ghrelin/growthhormonesecretagoguereceptor (GHSR) agonist, and was the first of this class of drugs...
of the ghrelin receptor and a growthhormonesecretagogue, mimicking the growthhormone (GH)-stimulating action of the endogenous hormone ghrelin. It has...
highly selective agonist of the ghrelin/growthhormonesecretagoguereceptor (GHSR) and a growthhormonesecretagogue which was developed by Mediolanum Farmaceutici...
orally-active, centrally-penetrant, selective agonist of the ghrelin/growthhormonesecretagoguereceptor (GHSR) with appetite-enhancing and anabolic effects which...
ghrelin, a growthhormonesecretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growthhormonesecretagoguereceptors in the pituitary...
adult growthhormone deficiency. Macimorelin acetate, the salt formulation, is a synthetic growthhormonesecretagoguereceptor agonist. It is a growth hormone...
Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide...
(BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin. Agonists Peptide Adiponectin...
peptide, centrally penetrant, selective agonist of the ghrelin/growthhormonesecretagoguereceptor (GHSR) which is under development by Allergan pharmaceuticals...
human G protein-coupled receptor genes (GPR38 and GPR39) related to the growthhormonesecretagogue and neurotensin receptors". Genomics. 46 (3): 426–434...
the ghrelin/growthhormonesecretagoguereceptor (GHSR-1a). Unlike many related drugs, ulimorelin has little or no effect on growthhormone (GH) release...
peripheral edema, injection site pruritus and diarrhea. List of growthhormonesecretagogues "Egrifta (tesamorelin for injection) for Subcutaneous Use. U...
orally-active agonist of the ghrelin/growthhormonesecretagoguereceptor (GHSR) and growthhormonesecretagogue, mimicking the effects of the endogenous...
to be the shortest fully functional fragment of GHRH. List of growthhormonesecretagogues Prakash A, Goa KL (August 1999). "Sermorelin: a review of its...
medication used for long-term weight management. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be...
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