Monoclonal immunoglobulin deposition disease information
Medical condition
Monoclonal immunoglobulin deposition disease
Other names
MIDD
Diagnostic method
Serum protein electrophoresis, Urine protein electrophroresis
Treatment
Bortezomib-based management, Organ transplant
Monoclonal immunoglobulin deposition disease, or MIDD, is a disease characterised by the deposition of monoclonal immunoglobulins on the basement membrane of the kidney. Monoclonal immunoglobulins are produced by monoclonal plasma cells, which are found in a variety of plasma cell dyscrasias. The deposition of monoclonal immunoglobulins on the basement membrane of the kidney causes renal impairment. As well as the kidney, MIDD may also affect the liver, heart, peripheral nerves, lung and skin.
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Monoclonalimmunoglobulindepositiondisease, or MIDD, is a disease characterised by the deposition of monoclonalimmunoglobulins on the basement membrane...
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deposits in the mesangium and glomerular basement membrane. Monoclonalimmunoglobulindepositiondisease (MIDD) involves light chains with unusual characteristics...
aggregate, the immunoglobulin level may be elevated with the disease, but the majority of such increased antibodies are of a monoclonal variety due to...
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presence of monoclonalimmunoglobulin is also done through immunofixation for detection of the monoclonal band. Presence of the monoclonal band would be...
cyclophosphamide, low dose IL-2, intravenous immunoglobulins, and belimumab. Omalizumab is a monoclonal antibody that interacts with the binding site...
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of infections. Primary amyloidosis (AL) is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells. Leukocyte...
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with high-dose intravenous corticosteroids, monoclonal antibodies, cyclophosphamide, intravenous immunoglobulin (IVIG), or plasmapheresis. For skin involvement...
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affects bone deposition (osteoblasts). In inflammatory arthritis conditions such as rheumatoid arthritis, psoriatic arthritis, and Crohn's disease, proinflammatory...
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collagen deposition. The deposition then influences the airway remodelling in asthmatic patients. Besides its well-established role in respiratory diseases IL-13...
when taking natalizumab. While monoclonal antibodies are probably going to have some role in the treatment of the disease in the future, it is believed...
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