"LCDD" redirects here. For other uses, see LCDD (disambiguation).
Medical condition
Light chain deposition disease
Other names
LCDD
Schematic diagram of a typical antibody showing two Ig heavy chains (blue) linked by disulfide bonds to two Ig light chains (green). The constant (C) and variable (V) domains are shown.
Specialty
Oncology
Light chain deposition disease (LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins, called light chains (LCs), in the body. LCs are normally cleared by the kidneys, but in LCDD, these light chain deposits damage organs and cause disease. The kidneys are almost always affected and this often leads to kidney failure. About half of people with light chain deposition disease also have a plasma cell dyscrasia, a spectrum of diseases that includes multiple myeloma, Waldenström's macroglobulinemia, and the monoclonal gammopathy of undetermined significance premalignant stages of these two diseases.[1][2] Unlike in AL amyloidosis, in which light chains are laid down in characteristic amyloid deposits, in LCDD, light chains are deposited in non-amyloid granules.[3]
^Kastritis (February 2009). "Treatment of light chain deposition disease with bortezomib and dexamethasone". Haematologica. 94 (2): 300–302. doi:10.3324/haematol.13548. PMC 2635400. PMID 19066331.
^UNC Kidney Center. "Light Chain Deposition Disease". UNC. Archived from the original on 22 December 2011. Retrieved 29 November 2011.
^Cite error: The named reference molecular level was invoked but never defined (see the help page).
and 25 Related for: Light chain deposition disease information
Lightchaindepositiondisease (LCDD) is a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins...
Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis. The disease is caused when a...
evidence of amyloid deposition (see Lightchaindepositiondisease), and d) an accumulation of 0.5 or more grams of the monoclonal lightchain in the urine over...
Amyloid lightchainsdeposition in shoulder joint causes enlarged shoulders, also known as "shoulder pad sign". Amyloid lightchaindepositions can also...
perfusion. For patients with light-chain amyloidosis, there can be depositions of amyloid into numerous different organs. Deposition of amyloid into other organs...
mixed) cryoglobulinemic disease. Signs and symptoms due to the cryoglobulins of type I disease reflect the hyperviscosity and deposition of cryoglobulins within...
as pigment deposition and hormone release in humans. Amyloids have been known to arise from many different proteins. These polypeptide chains generally...
include such diseases as Creutzfeldt–Jakob disease (and a variant associated with mad cow disease) and other prion diseases, Alzheimer's disease, Parkinson's...
composed of free lightchains. Quantitative measurements of the paraprotein are necessary to establish a diagnosis and to monitor the disease. The paraprotein...
sometimes sporadic ALS. The three mechanisms of disease associated with these C9orf72 repeats are deposition of RNA transcripts in the nucleus, translation...
proteins, especially immunoglobulin lightchain or transthyretin (TTR). It can be characterized by the extracellular deposition of amyloids, foldable proteins...
accumulation occurring very late in the disease. This is in contrast to transfusional iron overload in which iron deposition occurs first in the reticuloendothelial...
encephalopathy (BSE), commonly known as mad cow disease, is an incurable and invariably fatal neurodegenerative disease of cattle. Symptoms include abnormal behavior...
disease of the brain resulting from chronic iron deposition in neuronal tissues associated with cerebrospinal fluid. This occurs via the deposition of...
Frontotemporal dementia (FTD), also called frontotemporal degeneration disease or frontotemporal neurocognitive disorder, encompasses several types of...
plasmacytoma Monoclonal immunoglobulin depositiondiseases Primary amyloidosis Lightchain and heavy chaindepositiondiseases Extranodal marginal zone lymphoma...
AA amyloidosis is a form of amyloidosis, a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of...
amyloidosis, respectively. Amyloidosis is a disorder in which the abnormal deposition of a protein in organs and/or tissues gradually leads to organ failure...
by volcanic eruptions. "Acid rain" is a popular term referring to the deposition of a mixture from wet (rain, snow, sleet, fog, cloudwater, and dew) and...
can be classified into one-step solution deposition and two-step solution deposition. In one-step deposition, a perovskite precursor solution that is...
pains, and fevers) to severe (bleeding in the lungs or meningitis). Weil's disease (/ˈvaɪlz/ VILES), the acute, severe form of leptospirosis, causes the infected...
Global Information
