Methyllycaconitine (MLA) is a diterpenoid alkaloid found in many species of Delphinium (larkspurs).[1][2] In common with many other diterpenoid alkaloids, it is toxic to animals, although the acute toxicity varies with species.[3][4] Early research was focused on identifying, and characterizing the properties of methyllycaconitine as one of the principal toxins in larkspurs responsible for livestock poisoning in the mountain rangelands of North America.[3][5] Methyllycaconitine has been explored as a possible therapeutic agent for the treatment of spastic paralysis,[6] and it has been shown to have insecticidal properties.[7] Most recently, it has become an important molecular probe for studying the pharmacology of the nicotinic acetylcholine receptor.[8]
^Harbourne JB, Baxter H (1993). Phytochemical Dictionary. London: Taylor & Francis. p. 153.
^ abBenn MH, Jacyno JM. Pelletier SW (ed.). Chemical and Biological Perspectives. Vol. 1. New York: Wiley. pp. 153–210.
^Nation PN, Benn MH, Roth SH, Wilkens JL (September 1982). "Clinical signs and studies of the site of action of purified larkspur alkaloid, methyllycaconitine, administered parenterally to calves". The Canadian Veterinary Journal. 23 (9): 264–6. PMC 1790203. PMID 17422179.
^Aiyar VN, Benn MH, Hanna T, Jacyno J, Roth SH, Wilkens JL (October 1979). "The principal toxin of Delphinium brownii Rydb., and its mode of action". Experientia. 35 (10): 1367–8. doi:10.1007/BF01964013. PMID 499426. S2CID 19818861.
^Kabelianskaia LG (1959). "[Use of mellictin in clinical diseases of the nervous system in spastic paralysis]". Farmakologiia I Toksikologiia. 22 (1): 38–42. PMID 13653123.
^Jennings KR, Brown DG, Wright DP (1986). "Methyllycaconitine, a naturally occurring insecticide with a high affinity for the insect cholinergic receptor". Experientia. 42 (6): 611–613. doi:10.1007/BF01955557. S2CID 1460936.
^Wonnacott E, Albuquerque X, Bertrand D (1993). Conn PM (ed.). Methods in Neurosciences. Vol. 12. San Diego: Academic Press. pp. 263–275.
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