Membranoproliferative glomerulonephritis information
Medical condition
Membranoproliferative glomerulonephritis
Other names
Mesangiocapillary glomerulonephritis[1]
Micrograph of glomerulus in membranoproliferative glomerulonephritis with increased mesangial matrix and increased mesangial cellularity. Kidney biopsy. PAS stain.
Specialty
Nephrology
Membranoproliferative glomerulonephritis (MPGN) is a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (GBM) thickening,[2] activating the complement system and damaging the glomeruli.
MPGN accounts for approximately 4% of primary renal causes of nephrotic syndrome in children and 7% in adults.[3]
It should not be confused with membranous glomerulonephritis, a condition in which the basement membrane is thickened, but the mesangium is not.
^Colville D, Guymer R, Sinclair RA, Savige J (August 2003). "Visual impairment caused by retinal abnormalities in mesangiocapillary (membranoproliferative) glomerulonephritis type II ("dense deposit disease")". Am. J. Kidney Dis. 42 (2): E2–5. doi:10.1016/S0272-6386(03)00665-6. PMID 12900843.
^"membranoproliferative glomerulonephritis" at Dorland's Medical Dictionary
^Habib R, Gubler MC, Loirat C, Mäiz HB, Levy M (1975). "Dense deposit disease: a variant of membranoproliferative glomerulonephritis". Kidney Int. 7 (4): 204–15. doi:10.1038/ki.1975.32. PMID 1095806.
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rituximab. Similar promising results is shown in adults with Membranoproliferativeglomerulonephritis treated with Obinutuzumab after resistance to rituximab...
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lupus erythematosus is associated with low C3 and C4. Membranoproliferativeglomerulonephritis usually has low C3. The mechanism of complement deficiency...
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patient with membranoproliferativeglomerulonephritis diagnosed by the third biopsy via endocapillary proliferative glomerulonephritis and focal membranoproliferative...