Macrophage activation syndrome is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA). In addition, MAS has been described in association with systemic lupus erythematosus (SLE), Kawasaki disease, and adult-onset Still's disease. It is thought to be closely related and pathophysiologically very similar to reactive (secondary) hemophagocytic lymphohistiocytosis (HLH).[1] The incidence of MAS is unknown as there is a wide spectrum of clinical manifestations, and episodes may remain unrecognized.
Macrophageactivationsyndrome is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most...
idiopathic arthritis–associated macrophageactivationsyndrome, NLRC4 macrophageactivationsyndrome, cytokine release syndrome and sepsis. The term "cytokine...
cell death, failing to terminate macrophage and dendritic cell activation and causing macrophageactivationsyndrome. As indicated above, AIDs are caused...
lymphohistiocytosis and Macrophageactivationsyndrome. It has also been seen at autopsy of people who died of COVID-19. "Hemophagocytic Syndromes and Infection"...
childhood, including toxic shock and macrophageactivationsyndromes. Nevertheless, it appears to be a separate syndrome. Older children tend to be affected...
disease, some porphyrias, and hemophagocytic lymphohistiocytosis/macrophageactivationsyndrome are diseases in which the ferritin level may be abnormally raised...
(Venezuela) (Movimiento al Socialismo), a Venezuelan political party Macrophageactivationsyndrome, a potentially life-threatening complication of several chronic...
uncontrolled T lymphocyte expansion and macrophageactivationsyndrome. It is often associated with the hemophagocytic syndrome. This latter condition may be fatal...
dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils...
which results in chronic activation of Toll-like receptors and permeabilization of the phagolysosomal membrane, allowing activation of cytosolic sensors....
chemotaxis, proliferation, and activation of many immune cells. TGF-β is secreted by many cell types, including macrophages, in a latent form in which it...
Subramaniyam, S; Puthiyaveettil, J; Jayaprakash, R (March 2012). "Macrophageactivationsyndrome following Acinetobacter baumannii sepsis". International Journal...
techniques in the 1880s showed that microglia are related to macrophages. The activation of microglia and formation of ramified microglial clusters was...
tissue macrophages, blood monocytes, and epithelial cells of the genitourinary system and gastrointestinal tract. The three pathways of activation all generate...
which allows the DC to activate T cells. Via this process, immune complexes cause enhanced T cell activation. Type I FcγRs activation begins a cascade of...
increased risk of serious infections due to IL-1 blockade. Macrophageactivationsyndrome (MAS) is a known, life-threatening disorder that may develop...
coronary syndrome: markers of mast cell activation are found in people with ACS. The main marker of mast cell activation is inducible macrophage protein...
steroid use can cause contribute to the development of cataracts. Macrophageactivationsyndrome (MAS) is a severe, potentially life-threatening complication...
result, the macrophage expresses more CD40 and TNF receptors on its surface, which helps increase the level of activation. The activatedmacrophage can then...
(January 1992). "Complement, neutrophil, and macrophageactivation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and...
adalimumab, and etanercept. Tumor necrosis factors are critical in macrophageactivation and subsequent granuloma formation. Therefore, TNF antagonists impair...