negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4084
17119
Ensembl
ENSG00000059728
ENSMUSG00000001156
UniProt
Q05195
P50538
RefSeq (mRNA)
NM_002357 NM_001202513 NM_001202514
NM_010751
RefSeq (protein)
NP_001189442 NP_001189443 NP_002348
n/a
Location (UCSC)
Chr 2: 69.9 – 69.94 Mb
Chr 6: 86.62 – 86.65 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
MAD protein is a protein that in humans is encoded by the MXD1 gene.[5][6]
MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000059728 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001156 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shapiro DN, Valentine V, Eagle L, Yin X, Morris SW, Prochownik EV (February 1995). "Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25". Genomics. 23 (1): 282–5. doi:10.1006/geno.1994.1496. PMID 7829091.
^ ab"Entrez Gene: MXD1 MAX dimerization protein 1".
MAD protein is a protein that in humans is encoded by the MXD1 gene. MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This...
language), for Michigan Algorithm Decoder MAD, a protein encoded by the MXD1 gene Magnetic anomaly detector, detects variations in Earth's magnetic field...
MTF2 ENSG00000143033 Unknown Known motif – High-throughput in vitro [549] MXD1 ENSG00000059728 bHLH Inferred motif from similar protein – In vivo/Misc source...
Global Information
