The pacemaker current (If, or IKf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker.
First described in the late 1970s in Purkinje fibers and sinoatrial myocytes, the cardiac pacemaker "funny" (If) current has been extensively characterized and its role in cardiac pacemaking has been investigated.[1][2][3] Among the unusual features which justified the name "funny" are mixed Na+ and K+ permeability, activation on hyperpolarization, and very slow kinetics.[1]
^DiFrancesco D, Ojeda C (November 1980). "Properties of the current if in the sino-atrial node of the rabbit compared with those of the current iK, in Purkinje fibres". The Journal of Physiology. 308: 353–67. doi:10.1113/jphysiol.1980.sp013475. PMC 1274552. PMID 6262501.
^Baruscotti M, Bucchi A, Difrancesco D (July 2005). "Physiology and pharmacology of the cardiac pacemaker ("funny") current". Pharmacology & Therapeutics. 107 (1): 59–79. doi:10.1016/j.pharmthera.2005.01.005. PMID 15963351.
The pacemakercurrent (If, or IKf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel...
cells of the heart (e.g., the sinoatrial node), the pacemaker potential (also called the pacemakercurrent) is the slow, positive increase in voltage across...
An artificial cardiac pacemaker, commonly referred to as simply a pacemaker, is an implanted medical device that generates electrical pulses delivered...
are called pacemaker cells, and they directly control the heart rate. They make up the cardiac pacemaker, that is, the natural pacemaker of the heart...
the brand name Procoralan among others, is a medication, which is a pacemakercurrent (If) inhibitor, used for the symptomatic management of heart-related...
The current through HCN channels, designated If or Ih, plays a key role in the control of cardiac and neuronal rhythmicity and is called the pacemaker current...
Gerry and the Pacemakers were a British beat group prominent in the 1960s Merseybeat scene. In common with the Beatles, they came from Liverpool, were...
in the upper back wall of the right atrium made up of cells known as pacemaker cells. The sinus node is approximately 15 mm long, 3 mm wide, and 1 mm...
A biological pacemaker is one or more types of cellular components that, when "implanted or injected into certain regions of the heart," produce specific...
"pacemaker" current. The "Ik decay" hypothesis proposes that pacemaker depolarization results from slow deactivation of the delayed rectifier current,...
potassium and calcium currents, as well as the slow-inward sodium current that is thought to be responsible for the pacemakercurrent (If). By hyperpolarizing...
organization Isiah Kiner-Falefa (born 1995), American baseball player Pacemakercurrent of the heart, IKf This disambiguation page lists articles associated...
and collaborators discovered the so-called "funny" (or "pacemaker") current in cardiac pacemaker cells, a new mechanism involved in the generation of cardiac...
known as pacemaker cells, that have automatic action potential generation capability. In healthy hearts, these cells form the cardiac pacemaker and are...
increasing the slope of the pacemaker phase, while parasympathetic activation exerts the opposite action. The amount of net inward current required to move the...
later time. This contrasts with pacemaker potential or current which drives rhythmic modulation of firing rate. Some pacemaker action generate rhythms for...
The Pacemaker is a pocket-size DJ system invented by Jonas Norberg. The device features include a 120 GB hard drive, a signal-to-noise ratio of 103, and...
activity (ECA) is the spontaneous depolarization and repolarization of pacemaker cells known as interstitial cells of Cajal (ICCs) in the smooth muscle...
"Implantable pacemaker for the heart". In Smyth CN (ed.). Medical electronics. Paris: Iliffe & Sons. Warren J., Nelson J. (2000). "Pacemakers and ICD pulse...
Pacemaker crosstalk results when the pacemaker-generated electrical event in one heart chamber is sensed by the lead in another chamber, resulting in inappropriate...
limited its current load to under 0.1 mA and was thus considered useless. Greatbatch sought to introduce this invention into the pacemaker industry, which...
must operate unattended for long periods of time, such as spacecraft, pacemakers, underwater systems and automated scientific stations in remote parts...
device to the commercial market in the early 1970s. The Avery Breathing Pacemaker received pre-market approval from the FDA in 1987 for "chronic ventilatory...
The National Pacemaker Awards are awards for excellence in American student journalism, given annually since 1927. The awards are generally considered...
of a pacemaker has been advocated in a subset of individuals, in order to cause asynchronous contraction of the left ventricle. Since the pacemaker activates...
developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemakercurrent by altering the maximal channel conductance and alter the voltage...
cardiac arrest), and this risk is higher for those who use an artificial pacemaker or similar device or who have heart conditions. Because of this, it is...