Lymphotoxin beta information

LTB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MXW
Identifiers
Aliases	LTB, TNFC, TNFSF3, p33, Lymphotoxin beta, TNLG1C
External IDs	OMIM: 600978; MGI: 104796; HomoloGene: 1752; GeneCards: LTB; OMA:LTB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,582,522 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,415,296 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; blood; ; appendix; ; monocyte; ; bone marrow; ; bone marrow cells; ; duodenum; ; gallbladder; ; thymus;
	Top expressed in
	spleen; ; thymus; ; bone marrow; ; jejunum; ; colon; ; ileum; ; lung; ; duodenum; ; pancreas; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding;
Cellular component	integral component of membrane; plasma membrane; membrane; extracellular space; cellular component;
Biological process	cell-cell signaling; tumor necrosis factor-mediated signaling pathway; lymph node development; gene expression; immune response; signal transduction; skin development; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4050
	16994
ENSG00000223448; ENSG00000238114; ENSG00000236925; ENSG00000231314; ENSG00000204487;
	ENSG00000236237; ENSG00000227507; ENSG00000206437
	ENSMUSG00000024399
	Q06643
	P41155
	NM_009588; NM_002341
	NM_008518
	NP_002332; NP_033666
	NP_032544
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000238114, ENSG00000236925, ENSG00000231314, ENSG00000204487, ENSG00000236237, ENSG00000227507, ENSG00000206437 GRCh38: Ensembl release 89: ENSG00000223448, ENSG00000238114, ENSG00000236925, ENSG00000231314, ENSG00000204487, ENSG00000236237, ENSG00000227507, ENSG00000206437 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024399 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF (Mar 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell. 72 (6): 847–56. doi:10.1016/0092-8674(93)90574-A. PMID 7916655. S2CID 28961163.
^ Browning JL, Androlewicz MJ, Ware CF (Aug 1991). "Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma". Journal of Immunology. 147 (4): 1230–7. doi:10.4049/jimmunol.147.4.1230. PMID 1714477. S2CID 6160376.
^ "Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)".

[refGRCh38Ensembl-1] ENSG00000238114, ENSG00000236925, ENSG00000231314, ENSG00000204487, ENSG00000236237, ENSG00000227507, ENSG00000206437 GRCh38: Ensembl release 89: ENSG00000223448, ENSG00000238114, ENSG00000236925, ENSG00000231314, ENSG00000204487, ENSG00000236237, ENSG00000227507, ENSG00000206437 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024399 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7916655-5] Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF (Mar 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell. 72 (6): 847–56. doi:10.1016/0092-8674(93)90574-A. PMID 7916655. S2CID 28961163.

[pmid1714477-6] Browning JL, Androlewicz MJ, Ware CF (Aug 1991). "Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma". Journal of Immunology. 147 (4): 1230–7. doi:10.4049/jimmunol.147.4.1230. PMID 1714477. S2CID 6160376.

[entrez-7] "Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)".

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