Pharmaceutical drug
Loteprednol Trade names Lotemax Other names 11β,17α,Dihydroxy-21-oxa-21-chloromethylpregna-1,4-diene-3,20-dione 17α-ethylcarbonate AHFS/Drugs.com Micromedex Detailed Consumer Information Routes of administration Eye drops Drug class Corticosteroid; glucocorticoid ATC code Legal status
AU : S4 (Prescription only)[1]
US : ℞-only
Bioavailability None Protein binding 95% Metabolism Ester hydrolysis Metabolites Δ1 -cortienic acid and its etabonate Onset of action ≤2 hrs (allergic conjunctivitis) Elimination half-life 2.8 hrs
Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H -cyclopenta[a ]phenanthrene-17-carboxylate
CAS Number 82034-46-6 Y PubChem CID IUPHAR/BPS DrugBank DB14596 N ChemSpider 392049 N UNII KEGG D01689 Y ChEBI CHEBI:31784 N ChEMBL ChEMBL1200865 N CompTox Dashboard (EPA ) DTXSID2046468 ECHA InfoCard 100.167.120 Formula C 24 H 31 Cl O 7 Molar mass 466.96 g·mol−1 3D model (JSmol) Melting point 220.5 to 223.5 °C (428.9 to 434.3 °F) Solubility in water 0.0005 mg/mL (20 °C)
CCOC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C(=O)OCCl
InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
N Key:DMKSVUSAATWOCU-HROMYWEYSA-N
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Loteprednol (synthesized as the ester loteprednol etabonate ) is a topical corticosteroid used to treat inflammations of the eye. It is marketed by Bausch and Lomb as Lotemax [2] and Loterex .
It was patented in 1980 and approved for medical use in 1998.[3] It is available as a generic medication.[4]
^ "Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA) . 21 June 2022. Retrieved 10 April 2023 .
^ Cite error: The named reference AC
was invoked but never defined (see the help page).
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery . John Wiley & Sons. p. 488. ISBN 9783527607495 .
^ "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA) . 30 May 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023 .
Last Update: 2023-10-23T13:54:11Z
Loteprednol (synthesized as the ester loteprednol etabonate) is a topical corticosteroid used to treat inflammations of the eye. It is marketed by Bausch...
Word Count : 985
Last Update: 2022-12-30T00:16:09Z
corticosteroid eye drop, such as prednisolone acetate (Pred Forte) or loteprednol (Lotemax). Loteprednol is increasingly preferred due to its lower risk of elevating...
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Last Update: 2024-04-20T03:10:01Z
Alclometasone S01BA11 Desonide S01BA12 Formocortal S01BA13 Rimexolone S01BA14 Loteprednol S01BA15 Fluocinolone acetonide S01BA16 Difluprednate S01BB01 Hydrocortisone...
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Last Update: 2023-08-18T12:29:21Z
in the antigen challenge model. Ester based "soft" steroids such as loteprednol (Alrex) are typically sufficient to calm inflammation due to allergies...
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