Lipid raft organization, region (1) is a standard lipid bilayer, while region (2) is a lipid raft.
The plasma membranes of cells contain combinations of glycosphingolipids, cholesterol and protein receptors organised in glycolipoprotein lipid microdomains termed lipid rafts.[1][2][3] Their existence in cellular membranes remains controversial. Indeed, Kervin and Overduin imply that lipid rafts are misconstrued protein islands, which they propose form through a proteolipid code.[4] Nonetheless, it has been proposed that they are specialized membrane microdomains which compartmentalize cellular processes by serving as organising centers for the assembly of signaling molecules, allowing a closer interaction of protein receptors and their effectors to promote kinetically favorable interactions necessary for the signal transduction.[5] Lipid rafts influence membrane fluidity and membrane protein trafficking, thereby regulating neurotransmission and receptor trafficking.[3][6] Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely within the membrane bilayer.[7] Although more common in the cell membrane, lipid rafts have also been reported in other parts of the cell, such as the Golgi apparatus and lysosomes.
^Thomas, Sunil; Preda-Pais, Anca; Casares, Sofia; Brumeanu, Teodor-D (2004). "Analysis of lipid rafts in T cells". Molecular Immunology. 41 (4): 399–409. doi:10.1016/j.molimm.2004.03.022. PMID 15163537.
^Thomas, Sunil; Kumar S., Rajeev; Brumeanu, Teodor−D. (2004). "Role of lipid rafts in T cells". Archivum Immunologiae et Therapiae Experimentalis. 52 (4): 215–24. PMID 15467486.
^ abKorade, Zeljka; Kenworthy, Anne K. (2008). "Lipid rafts, cholesterol, and the brain". Neuropharmacology. 55 (8): 1265–73. doi:10.1016/j.neuropharm.2008.02.019. PMC 2638588. PMID 18402986.
^Kervin, TA; Overduin, M (27 February 2024). "Membranes are functionalized by a proteolipid code". BMC Biology. 22 (1): 46. doi:10.1186/s12915-024-01849-6. PMC 10898092. PMID 38414038.
^Alves, Anna Carolina Schneider; Dias, Reinaldo Antonio; Kagami, Luciano Porto; Neves, Gustavo Machado das; Torres, Fernando Cidade; Eifler-Lima, Vera Lucia; Carvalho, Ivone; Kawano*, Carolina de Miranda Silva and Daniel Fabio (2018-05-31). "Beyond the". Current Medicinal Chemistry. 25 (18): 2082–2104. doi:10.2174/0929867325666180111100601. PMID 29332565.
^Pike, L. J. (2008). "The challenge of lipid rafts". The Journal of Lipid Research. 50 (Suppl): S323–8. doi:10.1194/jlr.R800040-JLR200. PMC 2674732. PMID 18955730.
^Simons, Kai; Ehehalt, Robert (2002). "Cholesterol, lipid rafts, and disease". Journal of Clinical Investigation. 110 (5): 597–603. doi:10.1172/JCI16390. PMC 151114. PMID 12208858.
glycolipoprotein lipid microdomains termed lipidrafts. Their existence in cellular membranes remains controversial. Indeed, Kervin and Overduin imply that lipid rafts...
regions within the membrane with special lipid and protein cocoon that promote the formation of lipidrafts or protein and glycoprotein complexes. Another...
associated with lipid microdomains in the plasma membrane known as lipidrafts. Lipidrafts are characterized by the lipid molecules being in the lipid ordered...
intricate phase diagrams. One lipid-cholesterol system that has recently been studied intently is the lipidraft. Lipidrafts are cholesterol-enriched gel...
GM1 lipidrafts in response to astrocyte cholesterol. Cholesterol delivered by apolipoprotein E (ApoE) drives APP to associate with GM1 lipidrafts. When...
(Latin for "little caves"; singular, caveola), which are a special type of lipidraft, are small (50–100 nanometer) invaginations of the plasma membrane in...
associated with lipidrafts. It does so by controlling the formation or depletion of lipidrafts in the plasma membrane. The lipidrafts house the membrane...
slow process. Lipidrafts and caveolae are examples of cholesterol-enriched microdomains in the cell membrane. Also, a fraction of the lipid in direct contact...
The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a...
factor Hes3 and increases their numbers. GM1 gangliosides are found in lipidrafts on the cell surface. B subunit complexes labelled with fluorescent tags...
(see diagram) in cholesterol-rich lipid rafts areas of the membranes in eukaryotic cells. Formation of lipidrafts promotes aggregation of peripheral and...
of the myofibrillar myopathy diseases Detergent resistant membrane, a lipidraft Digestive rate model, the diet selection that animals should perform to...
microdomains (lipidrafts) occurs when PA63 binds to the receptor and heptamerizes. Once the receptor and PA returns to the lipidraft, E3 ubiquitin ligase...
studies in molecular and cell biology. Many of the studies of lipidrafts in artificial lipid systems have been performed with GUVs for this reason. Compared...
Monoglycosylceramides in conjunction with cholesterol are prevalent in the lipid-raft micro domain, which are important sites in the binding of proteins, and...
causing the enzyme to traffic to cholesterol dependent lipid domains sometimes called "lipidrafts". The substrate of phospholipase D is phosphatidylcholine...
(February 2020). "PEDV enters cells through clathrin-, caveolae-, and lipidraft-mediated endocytosis and traffics via the endo-/lysosome pathway". Veterinary...
the membrane skeleton. The presence of specialized structures named "lipidrafts" in the red blood cell membrane have been described by recent studies...
biophysical experiments and has been used to study various subjects such as lipidrafts. POPC is also used in systems mimicking the cell membrane such as Nanodiscs...
length and saturation is important in characterizing the cell. Lipidrafts occur when lipid species and proteins aggregate in domains in the membrane. These...
mitochondria by binding to the lipidraft regions of the MAM. However, the mutant form of this gene has a low affinity to the lipidraft regions, thereby diminishing...
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