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Lim-1 is a homeobox transcription factor. This transcription factor is found in adults in the cerebellum, kidneys, and cerebrum, but plays a larger role in development of the fetal head and the female reproductive tract during gestation. During development it is found in the anterior visceral endoderm, is in tissues formed by the primitive streak, and is required in both tissues for head formation.[1] Lim1 is a member of the LIM homeobox gene and encodes a 406 amino acid protein.[2]
^Shawlot, William; Wakamiya, Maki; Kwan, Kin Ming; Kania, Artur; Jessell, Thomas (November 15, 1999). "Lim1 Is Required in Both Primitive Streak-derived Tissues and Visceral Endoderm for Head Formation in the Mouse". Development. 126 (22): 4925–4932. doi:10.1242/dev.126.22.4925. PMID 10529411.
^Fujii, Tetsuya; Pichel, Jose; Taira, Masanori; Toyama, Reiko; Dawid, Igor; Westphal, Heiner (January 1994). "Expression Patterns of the Murine LIM Class Homeobox Gene Lim1 in the Developing Brain and Excretory System". Developmental Dynamics. 199 (1): 73–83. doi:10.1002/aja.1001990108. PMID 7909459.
and 8 Related for: Lim1 transcription factor information
transcriptionfactor heavily responsible for head development, there are many other factors that affect expression of the normal head phenotype. Lim1...
Lim1 or Lim-1 may refer to: Lim-1, a variant of the Mikoyan-Gurevich MiG-15 aircraft Lim1transcriptionfactor, in molecular biology lim ← 1 {\displaystyle...
Leuschner I, Mannweiler S, Ebner B, Hoefler G (2011). "Lim1, an embryonal transcriptionfactor, is absent in multicystic renal dysplasia, but reactivated...
4 different subfamilies: αLIM1, βLIM1, γLIM2, and δLIM2. The αLIM1 subclades include PLIM1, WLIM1, and FLIM (XLIM). βLIM1 is a new subfamily, so no current...
the Mullerian duct is regulated by sequential actions of BMP/Pax2 and FGF/Lim1 signaling". Development. 143 (19): 3549–3559. doi:10.1242/dev.137067. hdl:2433/252845...
C, Qin J (2001). "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase...
recently identified and designated MLP-b. MLP contains two LIM domains (LIM1 and LIM2), each being surrounded by glycine-rich regions, and the two separated...
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