LIMS1 information

LIMS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G47, 1NYP, 1U5S, 2COR, 2D8X, 2KBX, 3F6Q, 4HI8, 4HI9
Identifiers
Aliases	LIMS1, PINCH, PINCH-1, PINCH1, LIM zinc finger domain containing 1
External IDs	OMIM: 602567; MGI: 1195263; HomoloGene: 68428; GeneCards: LIMS1; OMA:LIMS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	108,687,246 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	58,260,513 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; gastrocnemius muscle; ; ascending aorta; ; muscle of thigh; ; decidua; ; tail of epididymis; ; Descending thoracic aorta; ; epithelium of colon; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	granulocyte; ; left lung lobe; ; genital tubercle; ; cardiac muscle tissue of left ventricle; ; sciatic nerve; ; soleus muscle; ; atrioventricular valve; ; corneal stroma; ; atrium; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; protein binding; protein kinase binding; zinc ion binding;
Cellular component	cytosol; membrane; cell-cell junction; focal adhesion; plasma membrane; cell junction; perinuclear region of cytoplasm; protein-containing complex; cytoplasm;
Biological process	cellular response to transforming growth factor beta stimulus; establishment of protein localization; positive regulation of GTPase activity; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of gene expression; epithelial to mesenchymal transition; positive regulation of focal adhesion assembly; regulation of epithelial cell proliferation; negative regulation of transcription, DNA-templated; cell junction assembly; positive regulation of cell-substrate adhesion; tumor necrosis factor-mediated signaling pathway; protein heterooligomerization; positive regulation of NIK/NF-kappaB signaling; cell-cell junction organization; cell-cell adhesion; positive regulation of integrin-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3987
	110829
	ENSG00000169756
	ENSMUSG00000019920
	P48059
	Q99JW4
NM_001193482; NM_001193483; NM_001193484; NM_001193485; NM_001193488;
	NM_004987
NM_001193303; NM_026148; NM_201242; NM_001346676; NM_001359115;
	NM_001359116
NP_001180411; NP_001180412; NP_001180413; NP_001180414; NP_001180417;
	NP_004978; NP_001358423; NP_001358424; NP_001358425; NP_001358426; NP_001358427; NP_001358428; NP_001358429
NP_001180232; NP_001333605; NP_080424; NP_957694; NP_001346044;
	NP_001346045
	Wikidata
View/Edit Human	View/Edit Mouse

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169756 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019920 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rearden A (Aug 1994). "A new LIM protein containing an autoepitope homologous to "senescent cell antigen"". Biochem. Biophys. Res. Commun. 201 (3): 1124–31. doi:10.1006/bbrc.1994.1822. PMID 7517666.
^ Tu Y, Li F, Goicoechea S, Wu C (Mar 1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Mol. Cell. Biol. 19 (3): 2425–34. doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169756 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019920 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7517666-5] Rearden A (Aug 1994). "A new LIM protein containing an autoepitope homologous to "senescent cell antigen"". Biochem. Biophys. Res. Commun. 201 (3): 1124–31. doi:10.1006/bbrc.1994.1822. PMID 7517666.

[pmid10022929-6] Tu Y, Li F, Goicoechea S, Wu C (Mar 1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Mol. Cell. Biol. 19 (3): 2425–34. doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

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La Trobe Institute for Molecular Science

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