CSRP3 information

CSRP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O10, 2O13
Identifiers
Aliases	CSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP, cysteine and glycine rich protein 3
External IDs	OMIM: 600824 MGI: 1330824 HomoloGene: 20742 GeneCards: CSRP3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	19,210,571 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	48,497,781 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; biceps brachii; ; thoracic diaphragm; ; vastus lateralis muscle; ; triceps brachii muscle; ; body of tongue; ; vena cava; ; deltoid muscle; ; tibialis anterior muscle; ; gastrocnemius muscle;
	Top expressed in
	atrioventricular valve; ; endocardial cushion; ; interventricular septum; ; right ventricle; ; cardiac muscles; ; myocardium of ventricle; ; ankle; ; atrium; ; esophagus; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actinin binding; metal ion binding; telethonin binding; protein binding; structural constituent of muscle; actin binding; identical protein binding;
Cellular component	cytoplasm; Z disc; cytoskeleton; nucleus; sarcomere;
Biological process	protein localization to organelle; cell differentiation; negative regulation of myoblast differentiation; cardiac muscle contraction; cardiac muscle tissue development; regulation of the force of heart contraction; cardiac muscle hypertrophy; muscle organ development; cellular calcium ion homeostasis; positive regulation of actin filament severing; detection of muscle stretch; cardiac myofibril assembly; multicellular organism development; positive regulation of myoblast differentiation; negative regulation of actin filament severing; skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription, DNA-templated; inflammatory response; heart development; insulin receptor signaling pathway; T-tubule organization; glucose homeostasis; protein kinase C signaling; regulation of protein localization to plasma membrane; actin cytoskeleton organization; sarcomere organization; muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	8048
	13009
	ENSG00000129170
	ENSMUSG00000030470
	P50461
	P50462
	NM_003476; NM_001369404
	NM_001198841; NM_013808
	NP_003467
	NP_001185770; NP_038836
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine and glycine-rich protein 3 also known as cardiac LIM protein (CLP) or muscle LIM protein (MLP) is a protein that in humans is encoded by the CSRP3 gene.^[5]

CSRP3 IS a small 194 amino acid protein, which is specifically expressed in skeletal and cardiac muscle.^[6]^[7] In rodents, CSRP3 has also been found to be expressed in neurons.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129170 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arber S, Halder G, Caroni P (October 1994). "Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation". Cell. 79 (2): 221–31. doi:10.1016/0092-8674(94)90192-9. PMID 7954791. S2CID 26650433.
^ Gehmlich K, Geier C, Milting H, Fürst D, Ehler E (2008). "Back to square one: what do we know about the functions of muscle LIM protein in the heart?". Journal of Muscle Research and Cell Motility. 29 (6–8): 155–8. doi:10.1007/s10974-008-9159-4. PMID 19115046. S2CID 9251900.
^ Knöll R, Hoshijima M, Chien KR (2001). "Muscle LIM protein in heart failure". Experimental and Clinical Cardiology. 7 (2–3): 104–5. PMC 2719181. PMID 19649232.
^ Levin E, Leibinger M, Gobrecht P, Hilla A, Andreadaki A, Fischer D (January 2019). "Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration". Cell Reports. 26 (4): 1021–1032.e6. doi:10.1016/j.celrep.2018.12.026. PMID 30673598.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129170 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[a3-5] Arber S, Halder G, Caroni P (October 1994). "Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation". Cell. 79 (2): 221–31. doi:10.1016/0092-8674(94)90192-9. PMID 7954791. S2CID 26650433.

[a1-6] Gehmlich K, Geier C, Milting H, Fürst D, Ehler E (2008). "Back to square one: what do we know about the functions of muscle LIM protein in the heart?". Journal of Muscle Research and Cell Motility. 29 (6–8): 155–8. doi:10.1007/s10974-008-9159-4. PMID 19115046. S2CID 9251900.

[a2-7] Knöll R, Hoshijima M, Chien KR (2001). "Muscle LIM protein in heart failure". Experimental and Clinical Cardiology. 7 (2–3): 104–5. PMC 2719181. PMID 19649232.

[Levin_2019-8] Levin E, Leibinger M, Gobrecht P, Hilla A, Andreadaki A, Fischer D (January 2019). "Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration". Cell Reports. 26 (4): 1021–1032.e6. doi:10.1016/j.celrep.2018.12.026. PMID 30673598.

CSRP3 information

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List of OMIM disorder codes

Telethonin