ROCK1 information

ROCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML
Identifiers
Aliases	ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1
External IDs	OMIM: 601702; MGI: 107927; HomoloGene: 55899; GeneCards: ROCK1; OMA:ROCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	21,111,813 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	10,182,045 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; popliteal artery; ; tibial arteries; ; monocyte; ; right coronary artery; ; bone marrow cells; ; left coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; epithelium of colon;
	Top expressed in
	tunica media of zone of aorta; ; Rostral migratory stream; ; zygote; ; secondary oocyte; ; ciliary body; ; ascending aorta; ; primary oocyte; ; lacrimal gland; ; aortic valve; ; left lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; tau protein binding; tau-protein kinase activity; Rho-dependent protein serine/threonine kinase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; membrane; ruffle; Golgi membrane; plasma membrane; bleb; centriole; cytoskeleton; lamellipodium; extracellular region; secretory granule lumen; cytoplasmic stress granule; amyloid-beta complex;
Biological process	negative regulation of neuron apoptotic process; leukocyte cell-cell adhesion; smooth muscle contraction; myoblast migration; intracellular signal transduction; regulation of actin cytoskeleton organization; phosphorylation; ephrin receptor signaling pathway; bleb assembly; negative regulation of protein binding; regulation of actin filament-based process; regulation of stress fiber assembly; regulation of cell motility; protein phosphorylation; negative regulation of bicellular tight junction assembly; vascular endothelial growth factor receptor signaling pathway; regulation of cell adhesion; Rho protein signal transduction; membrane to membrane docking; leukocyte tethering or rolling; regulation of focal adhesion assembly; negative regulation of angiogenesis; regulation of keratinocyte differentiation; positive regulation of focal adhesion assembly; negative regulation of myosin-light-chain-phosphatase activity; I-kappaB kinase/NF-kappaB signaling; regulation of establishment of cell polarity; cortical actin cytoskeleton organization; apical constriction; regulation of establishment of endothelial barrier; actin cytoskeleton organization; leukocyte migration; signal transduction; regulation of cytoskeleton organization; apoptotic process; neutrophil degranulation; execution phase of apoptosis; protein localization to plasma membrane; G protein-coupled receptor signaling pathway; aortic valve morphogenesis; regulation of autophagy; positive regulation of autophagy; positive regulation of cardiac muscle hypertrophy; positive regulation of gene expression; peptidyl-serine phosphorylation; neuron projection development; positive regulation of MAPK cascade; regulation of neuron differentiation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of biomineral tissue development; response to transforming growth factor beta; regulation of angiotensin-activated signaling pathway; neuron projection arborization; positive regulation of amyloid-beta clearance; regulation of synaptic vesicle endocytosis; regulation of amyloid-beta formation; negative regulation of amyloid-beta formation; negative regulation of amyloid precursor protein catabolic process; positive regulation of connective tissue replacement; response to angiotensin; mRNA destabilization; blood vessel diameter maintenance; mitotic cytokinesis; peptidyl-threonine phosphorylation; actomyosin structure organization; embryonic morphogenesis; regulation of cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	6093
	19877
	ENSG00000067900
	ENSMUSG00000024290
	Q13464
	P70335
	NM_005406
	NM_009071
	NP_005397
	NP_033097
	Wikidata
View/Edit Human	View/Edit Mouse

ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation.^[5] ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000067900 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024290 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Rath N, Olson MF (October 2012). "Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy". EMBO Reports. 13 (10): 900–8. doi:10.1038/embor.2012.127. PMC 3463970. PMID 22964758.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000067900 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024290 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Rath_Olson_2012-5] Rath N, Olson MF (October 2012). "Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy". EMBO Reports. 13 (10): 900–8. doi:10.1038/embor.2012.127. PMC 3463970. PMID 22964758.

ROCK1 information

and 20 Related for: ROCK1 information

ROCK1

Rock

Rho family of GTPases

Rho kinase inhibitor

Transforming protein RhoA

Anaplasma phagocytophilum

Apoptosis

Ripasudil

Actomyosin ring

Wee1

MTOR

Protein kinase B

Titin

MTOR inhibitors

MTORC1

RAF kinase

Pleckstrin homology domain

Protein kinase A

MAP kinase kinase kinase kinase

Protein kinase C