RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular component
transcription regulator complex
intracellular anatomical structure
nucleus
Biological process
ventral spinal cord interneuron specification
cell differentiation
pituitary gland development
regulation of transcription, DNA-templated
spinal cord association neuron differentiation
spinal cord motor neuron cell fate specification
placenta development
lung development
negative regulation of apoptotic process
transcription, DNA-templated
positive regulation of transcription, DNA-templated
animal organ morphogenesis
inner ear development
medial motor column neuron differentiation
motor neuron axon guidance
dorsal/ventral pattern formation
transcription by RNA polymerase II
positive regulation of transcription by RNA polymerase II
neuron differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8022
16871
Ensembl
ENSG00000107187
ENSMUSG00000026934
UniProt
Q9UBR4
P50481
RefSeq (mRNA)
NM_014564 NM_178138 NM_001363746
NM_001039653 NM_010711
RefSeq (protein)
NP_055379 NP_835258 NP_001350675
NP_001034742 NP_034841
Location (UCSC)
Chr 9: 136.2 – 136.21 Mb
Chr 2: 26.09 – 26.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000107187 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026934 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ (Jan 2000). "Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties". Mol Endocrinol. 13 (12): 2212–25. doi:10.1210/me.13.12.2212. PMID 10598593.
^Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ (May 2000). "Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9". Gene. 245 (2): 237–43. doi:10.1016/S0378-1119(00)00025-1. PMID 10717474.
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene. LHX3 encodes a protein of a large protein family, members of which carry...
actually being a crossbreed with the Norwegian Elkhound. A mutation for the LHX3 gene causes pituitary dwarfism in the German Shepherd Dog. This mutation...
POU1F1 and PROP1 genes are responsible for the defect a mutation in the LHX3 gene is responsible for the condition. The University of Utrecht offers a...
hormone deficiencies (CPHD) in childhood. These are HESX1, PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. Each transcription factor acts in particular...
ENSG00000106689 Homeodomain Known motif – High-throughput in vitro [487] HHDTTR LHX3 ENSG00000107187 Homeodomain Known motif – from protein with 100% identical...
of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development". Gene Expr...
adaptor nuclear LIM interactor (NLI) bound to two LIM homeobox protein 3 (Lhx3), genes related to V2 interneuron identity are expressed. A dimer of the...
"A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci". Hum. Mol. Genet. 19 (11): 2303–12....
transcription of insulin. LMX1A has been shown to interact with TCF3 and LHX3. GRCh38: Ensembl release 89: ENSG00000162761 – Ensembl, May 2017 GRCm38:...
(2003). "Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal...
Global Information
