Protein-coding gene in the species Homo sapiens
HESX1 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases HESX1 , ANF, CPHD5, RPX, HESX homeobox 1External IDs OMIM: 601802 MGI: 96071 HomoloGene: 20831 GeneCards: HESX1 Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.3 Start 57,197,838 bp[1] End 57,227,606 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 26,716,373 bp[2] End 26,724,286 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right adrenal gland monocyte left adrenal gland body of pancreas gallbladder body of stomach skin of abdomen right coronary artery islet of Langerhans
Top expressed in endoderm blastocyst morula yolk sac Stomodeum mesoderm white adipose tissue kidney placenta renal cortex
More reference expression data
BioGPS
Gene ontology Molecular function
sequence-specific DNA binding
protein C-terminus binding
chromatin binding
protein binding
protein N-terminus binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component Biological process
multicellular organism development
forebrain morphogenesis
brain development
nose development
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
transcription, DNA-templated
otic vesicle formation
negative regulation of transcription by RNA polymerase II
pituitary gland development
regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_003865
RefSeq (protein) NP_003856
Location (UCSC) Chr 3: 57.2 – 57.23 Mb Chr 14: 26.72 – 26.72 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Homeobox expressed in ES cells 1 , also known as homeobox protein ANF , is a homeobox protein that in humans is encoded by the HESX1 gene.[5]
Expression of HEX1 and HESX1 marks the anterior visceral endoderm of the embryo. The AVE is an extra-embryonic tissue, key to the establishment of the anterior-posterior body axis.
^ a b c GRCh38: Ensembl release 89: ENSG00000163666 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Entrez Gene: HESX homeobox 1".
Last Update: 2022-03-30T16:00:52Z
is a homeobox protein that in humans is encoded by the HESX1 gene. Expression of HEX1 and HESX1 marks the anterior visceral endoderm of the embryo. The...
Word Count : 1024
Last Update: 2023-08-18T23:10:31Z
variant of Pickardt's syndrome that is associated with certain mutations (HESX1 or LHX4) is referred to as pituitary stalk interruption syndrome (PSIS)...
Word Count : 372
Last Update: 2023-02-28T13:28:55Z
M, Wales JK, Hindmarsh PC, Krauss S. Mutations in the homeobox gene HESX1 /Hesx1 associated with septo-optic dysplasia in human and mouse. Nature Genetics...
Word Count : 477
Last Update: 2024-04-01T17:00:44Z
DMBX1; DPRX; DRGX; DUXA, DUXB, DUX (1, 2, 3, 4, 4c, 5); ESX1; GSC, GSC2; HESX1 ; HOPX; ISX; LEUTX; MIXL1; NOBOX; OTP; OTX1, OTX2, CRX; PAX2, PAX3, PAX4...
Word Count : 4469
Last Update: 2024-03-27T12:48:29Z
combined pituitary hormone deficiencies (CPHD) in childhood. These are HESX1 , PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. Each transcription factor...
Word Count : 4441
Last Update: 2023-12-26T23:26:58Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 6676
Last Update: 2023-12-27T10:03:10Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 1999
Last Update: 2024-03-29T02:45:54Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 9499
Last Update: 2023-09-23T02:10:54Z
ENSG00000179111 bHLH Known motif – High-throughput in vitro [341] YGGCACGTGCCR HESX1 ENSG00000163666 Homeodomain Known motif – High-throughput in vitro [342]...
Word Count : 81
Last Update: 2023-11-15T21:06:22Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 542
Last Update: 2024-05-09T09:39:54Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 1741
Last Update: 2024-05-20T07:08:45Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 3402
Last Update: 2024-05-05T19:40:59Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 4825
Last Update: 2024-03-10T10:01:05Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 7188
Last Update: 2023-11-29T00:43:06Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 702
Last Update: 2023-12-21T15:03:20Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 2710
Last Update: 2024-04-13T08:04:48Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 2243
Last Update: 2022-11-25T21:03:19Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 514
Last Update: 2024-02-19T19:08:01Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 2796
Last Update: 2024-02-13T23:16:58Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 2688
Last Update: 2023-10-25T05:58:06Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 2049
Last Update: 2024-05-15T10:10:02Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 1978
Last Update: 2022-06-03T20:14:44Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 593
Last Update: 2024-04-04T22:42:44Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 1247
Last Update: 2024-05-02T19:41:07Z
Antennapedia ANTP class other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1 2 SIX 1 2 3 4 5 PHF...
Word Count : 720
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