LHX6 information

LHX6
Identifiers
Aliases	LHX6, LHX6.1, LIM homeobox 6, hLHX6
External IDs	OMIM: 608215; MGI: 1306803; HomoloGene: 7401; GeneCards: LHX6; OMA:LHX6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	122,229,626 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	35,995,420 bp
RNA expression pattern
	Top expressed in
	gonad; ; subcutaneous adipose tissue; ; prefrontal cortex; ; anterior cingulate cortex; ; endothelial cell; ; orbitofrontal cortex; ; Brodmann area 46; ; ganglionic eminence; ; visceral pleura; ; parietal pleura;
	Top expressed in
	medial ganglionic eminence; ; maxillary prominence; ; molar; ; entorhinal cortex; ; barrel cortex; ; CA3 field; ; perirhinal cortex; ; mandibular prominence; ; globus pallidus; ; female urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	multicellular organism development; cerebral cortex GABAergic interneuron migration; cell differentiation; regulation of transcription, DNA-templated; cerebral cortex radially oriented cell migration; cerebral cortex tangential migration; cell maturation; transcription, DNA-templated; nervous system development; regulation of transcription by RNA polymerase II; forebrain neuron development; neuron differentiation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	26468
	16874
	ENSG00000106852
	ENSMUSG00000026890
	Q9UPM6
	Q9R1R0
NM_001242333; NM_001242334; NM_001242335; NM_014368; NM_199160;
	NM_001348190
	NM_001083125; NM_001083126; NM_001083127; NM_008500; NM_001355125
NP_001229262; NP_001229263; NP_001229264; NP_055183; NP_954629;
	NP_001335119; NP_001229263.1
	NP_001076594; NP_001076595; NP_001076596; NP_032526; NP_001342054
	Wikidata
View/Edit Human	View/Edit Mouse

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.^[5]^[6]

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106852 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026890 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kimura N, Ueno M, Nakashima K, Taga T (Oct 1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains". J Biochem. 126 (1): 180–7. doi:10.1093/oxfordjournals.jbchem.a022420. PMID 10393337.
^ ^a ^b "Entrez Gene: LHX6 LIM homeobox 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106852 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026890 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10393337-5] Kimura N, Ueno M, Nakashima K, Taga T (Oct 1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains". J Biochem. 126 (1): 180–7. doi:10.1093/oxfordjournals.jbchem.a022420. PMID 10393337.

[entrez-6] "Entrez Gene: LHX6 LIM homeobox 6".

LHX6 information

and 6 Related for: LHX6 information

LHX6

List of human transcription factors

Homeobox

Benthonellania oligostigma

TMEM101

Gloria Choi