Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems.
two main types of kininogen (KNG), high-molecular-weight-kininogen and low-molecular-weight-kininogen, with a third type – T-kininogen – only found in rats...
encoded by the KNG1 gene. Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin...
plasma contact system by binding to factor XII and high molecular weight kininogen". Journal of Biological Chemistry. 277 (31): 27651–8. doi:10.1074/jbc...
Kallikrein, an enzyme that proteolytically cleaves high-molecular-weight kininogen to produce bradykinin, which is a vasodilator; it is secreted by the acinar...
formation of the primary complex on collagen by high-molecular-weight kininogen (HMWK), prekallikrein, and FXII (Hageman factor). Prekallikrein is converted...
an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease...
of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin Plasma kallikrein and its precursor are encoded...
makes bradykinin by proteolytic cleavage of its kininogen precursor, high-molecular-weight kininogen (HMWK or HK), by the enzyme kallikrein. Moreover...
with mutations in genes for Factor XII, angiopoietin 1, plasminogen or kininogen 1. The pathophysiologic mechanisms contributing to bradykinin mediated...
subsequent proteolysis of kininogen. The proteolysis of the kininogen forces an upscaled production of bradykinin and kininogen within the patient. Increased...
that directly releases bradykinin from high- and low-molecular-weight kininogen. Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin...
HMWK may refer to: High-molecular-weight keratin High-molecular-weight kininogen This disambiguation page lists articles associated with the title HMWK...
members of the autacoid family. Kinins are peptides that are cleaved from kininogens by the process of kallikreins. Kallikreins activate kinins when stimulated...
kallikrein, which liberates the kinins bradykinin and kallidin from their kininogen precursors and is produced in excess in individuals with HAE types I and...
on a biopolymer surface and is later replaced by high molecular weight kininogen. The process is delayed in narrow spaces and on hydrophobic surfaces,...
Plasma kallikrein liberates kinins (bradykinin and kallidin) from the kininogens, peptides responsible for the regulation of blood pressure and activation...
contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and glycoprotein Ib and the fourth...
blood, factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK), bind to a surface and cause blood coagulation and inflammation....
selectively release kallidin (lysyl-bradykinin, a bioactive kinin) from kininogen (a kinin protein precursor). Fiedler F, Fink E, Tschesche H, Fritz H (1981)...
Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins. Kallidin is a decapeptide whose...
subdivided as described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins...
contact factors, prekallikrein (Fletcher factor) and high molecular weight kininogen. Excess levels of factor XII can predispose individuals towards greater...
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