Plasma kallikrein (EC 3.4.21.34) is an enzyme[5][6][7][8][9] that catalyses the following chemical reaction:
Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin
Plasma kallikrein and its precursor are encoded by the KLKB1 gene.[10][11]
This enzyme is formed from prekallikrein (Fletcher factor) by factor XIIa.
^ abcGRCh38: Ensembl release 89: ENSG00000164344 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000109764 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Heimark RL, Davie EW (1981). "[14] Bovine and human plasma prekallikrein". Bovine and human plasma prekallikrein. Methods in Enzymology. Vol. 80 Pt C. pp. 157–72. doi:10.1016/s0076-6879(81)80016-x. ISBN 978-0-12-181980-4. PMID 6918767.
^McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC (December 1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20 (25): 7196–206. doi:10.1021/bi00528a022. PMID 6976185.
^Silverberg M, Kaplan AP (1988). "[8] Prekallikrein". Prekallikrein. Methods in Enzymology. Vol. 163. pp. 85–95. doi:10.1016/0076-6879(88)63010-2. ISBN 978-0-12-182064-0. PMID 3237096.
^Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chrétien M (October 1989). "The cDNA structure of rat plasma kallikrein". DNA. 8 (8): 563–74. doi:10.1089/dna.1989.8.563. PMID 2598771.
^Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S (November 1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chemical & Pharmaceutical Bulletin. 37 (11): 3108–11. doi:10.1248/cpb.37.3108. PMID 2534361.
^Yu H, Bowden DW, Spray BJ, Rich SS, Freedman BI (April 1998). "Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease". Hypertension. 31 (4): 906–11. doi:10.1161/01.hyp.31.4.906. PMID 9535413.
^Chung DW, Fujikawa K, McMullen BA, Davie EW (August 1986). "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats". Biochemistry. 25 (9): 2410–7. doi:10.1021/bi00357a017. PMID 3521732.
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasmakallikrein (encoded by KLKB1...
Plasmakallikrein (EC 3.4.21.34) is an enzyme that catalyses the following chemical reaction: Selective cleavage of some Arg- and Lys- bonds, including...
PK is the precursor of plasmakallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII...
Takhzyro, is a human monoclonal antibody (class IgG1 kappa) that targets plasmakallikrein (pKal) in order to promote prevention of angioedema in people with...
plasma protein that is an important inhibitor of several serine proteases, specially of the complement system and the contact activation/kallikrein-kinin...
reversibly inhibiting the activity of plasmakallikrein. Ecallantide's inhibitory constant (Ki) for kallikrein is 25 picoMolar, indicating high affinity...
inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasmakallikrein". Thrombosis and...
Urinary kallikrein may refer to: Plasmakallikrein, an enzyme Renal tissue kallikrein, an enzyme This set index page lists enzyme articles associated...
Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of factor XIIa (EC 3.4.21.38)...
Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. GRCh38: Ensembl release 89:...
PMC 2142190. PMID 1304909. Lehmann, A (2008). "Ecallantide (DX-88), a plasmakallikrein inhibitor for the treatment of hereditary angioedema and the prevention...
development programs include: Berotralstat (BCX7353), an oral inhibitor of plasmakallikrein for prevention and treatment of hereditary angioedema (HAE). FDA has...
preproadrenomedullin, consists of 185 amino acids and can be cleaved by plasmakallikrein at the Lys-Arg and Arg-Arg sites. By RNA-blot analysis, human adrenomedullin...
proteases and HK is a non-enzymatic co-factor. The CAS can activate the kinin–kallikrein system and blood coagulation through its ability to activate multiple...
at Celera Genomics, studying inhibitor compounds of human plasma proteins such as kallikrein and Factors VIIa and IXa. She was recruited to Genentech in...
is not activated until entering the acidic environment of the stomach Kallikrein, an enzyme that proteolytically cleaves high-molecular-weight kininogen...
the kallikrein-kinin system. In: The Kinin System. Academic Press, San Diego, CA, 1997. Beraldo WT, Siqueira G, Heneine IF. Kallikrein and kallikrein inhibitor...
PMID 4297812. S2CID 4245271. Jackman HL, Tan F, Schraufnagel D, et al. (1995). "Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages"....
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