plus-end-directed vesicle transport along microtubule
antigen processing and presentation of exogenous peptide antigen via MHC class II
mitotic spindle organization
anterograde axonal transport
positive regulation of cytokinesis
mitotic spindle assembly
determination of left/right symmetry
mitotic centrosome separation
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
microtubule-based movement
intraciliary transport involved in cilium assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9371
16569
Ensembl
ENSG00000101350
ENSMUSG00000027475
UniProt
O15066
Q61771
RefSeq (mRNA)
NM_004798
NM_008444
RefSeq (protein)
NP_004789
NP_032470
Location (UCSC)
Chr 20: 32.28 – 32.34 Mb
Chr 2: 153.13 – 153.18 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.[5][6] KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors.[7] First, KIF3B forms a heterodimer with KIF3A (kinesin-like protein KIF3A); (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 (KAP3, kinesin superfamily associated protein–3) binds to the tail domain to form a heterotrimeric motor.[7] This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a.[8] There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes.[9] Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.[7]
There are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, and Rattus norvegicus.
^ abcGRCh38: Ensembl release 89: ENSG00000101350 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027475 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
^"Entrez Gene: KIF3B kinesin family member 3B".
^ abcHirokawa N (January 1998). "Kinesin and dynein superfamily proteins and the mechanism of organelle transport". Science. 279 (5350): 519–26. Bibcode:1998Sci...279..519H. doi:10.1126/science.279.5350.519. PMID 9438838.
^Hirokawa N (January 1998). "Kinesin and dynein superfamily proteins and the mechanism of organelle transport". Science. 279 (5350): 519–26. Bibcode:1998Sci...279..519H. doi:10.1126/science.279.5350.519. PMID 9438838.
^Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, et al. (October 2004). "A standardized kinesin nomenclature". The Journal of Cell Biology. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732.
Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene. KIF3B is an N-type protein that complexes with two other kinesin...
insulin stimulation, which is then associated with KIF3B. Therefore, it is indicated that the KIF3B motor protein can then attach to the microtubule, allowing...
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