JUNB information

JUNB
Identifiers
Aliases	JUNB, AP-1, JunB proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 165161; MGI: 96647; HomoloGene: 7390; GeneCards: JUNB; OMA:JUNB - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,793,315 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,705,347 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; granulocyte; ; monocyte; ; tibial arteries; ; vena cava; ; saphenous vein; ; left ovary; ; nipple; ; trachea;
	Top expressed in
	granulocyte; ; lip; ; superior surface of tongue; ; spermatid; ; spermatocyte; ; corneal stroma; ; visual cortex; ; esophagus; ; transitional epithelium of urinary bladder; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; chromatin; nucleus; transcription factor AP-1 complex; transcription regulator complex;
Biological process	cellular response to calcium ion; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of cell death; osteoclast differentiation; labyrinthine layer blood vessel development; in utero embryonic development; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of cell cycle; vasculogenesis; embryonic process involved in female pregnancy; response to lipopolysaccharide; decidualization; regulation of cell population proliferation; trophectodermal cell differentiation; osteoblast differentiation; positive regulation of cell differentiation; response to radiation; osteoblast proliferation; cellular process; response to cAMP; response to mechanical stimulus; transcription, DNA-templated; cellular response to hormone stimulus; response to cytokine; positive regulation of transcription by RNA polymerase II; cytokine-mediated signaling pathway; response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	3726
	16477
	ENSG00000171223
	ENSMUSG00000052837
	P17275
	P09450
	NM_002229
	NM_008416
	NP_002220
	NP_032442
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene.^[5]^[6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171223 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052837 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129.
^ "Entrez Gene: JUNB jun B proto-oncogene".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171223 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052837 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2513129-5] Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi:10.1016/0092-8674(89)90755-1. PMID 2513129.

[6] "Entrez Gene: JUNB jun B proto-oncogene".

JUNB information

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