Familial disseminated comedones without dyskeratosis | |
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This condition is inherited via an autosomal dominant manner | |
Specialty | Dermatology |
Familial disseminated comedones without dyskeratosis (FDCWD) is a rare autosomal dominant skin disorder characterized by the presence of numerous comedones (blackheads and whiteheads) on the face, trunk, and extremities.[1] The comedones are typically asymptomatic and do not lead to scarring. The disorder is thought to be caused by a mutation in the gene encoding the protein involucrin.
The first case of FDCWD was reported in 1972.[2] Since then, there have been approximately 100 additional cases reported in the literature.[1] The disorder appears to be more common in people of Asian descent.
The diagnosis of FDCWD is made clinically. There is no specific laboratory test or biopsy finding that is diagnostic of the disorder. The differential diagnosis includes other disorders that can cause comedones, such as acne vulgaris, familial dyskeratotic comedones, and Darier-White disease.
There is no cure for FDCWD. Treatment is aimed at controlling the comedones and preventing scarring. Treatment options include topical retinoids, oral isotretinoin, and chemical peels.
The prognosis for FDCWD is good. The comedones typically do not worsen over time and do not lead to any serious health problems.
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