Intestinal permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. The intestine normally exhibits some permeability, which allows nutrients to pass through the gut, while also maintaining a barrier function to keep potentially harmful substances (such as antigens) from leaving the intestine and migrating to the body more widely.[1] In a healthy human intestine, small particles (< 4 Å in radius) can migrate through tight junction claudin pore pathways,[2] and particles up to 10–15 Å (3.5 kDa) can transit through the paracellular space uptake route.[3] There is some evidence abnormally increased intestinal permeability may play a role in some chronic diseases and inflammatory conditions.[4] The most well understood condition with observed increased intestinal permeability is celiac disease.[5]
^M. Campieri; C. Fiocchi; S.B. Hanauer (31 March 2002). Inflammatory Bowel Disease: A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment. Springer. p. 7. ISBN 978-0-7923-8772-5.
^Thoma YM, Anderson JM, Turner JR (2012). Johnson LR, et al. (eds.). Tight Junctions and the Intestinal Barrier. Vol. 1. Academic Press. pp. 1043–. ISBN 978-0-12-382027-3. {{cite book}}: |work= ignored (help)
^Fasano, A. (February 2012). "Leaky Gut and Autoimmune Diseases". Clinical Reviews in Allergy & Immunology (Review). 42 (1): 71–78. doi:10.1007/s12016-011-8291-x. PMID 22109896. S2CID 4088994.
^Cite error: The named reference Fasano was invoked but never defined (see the help page).
^Cite error: The named reference LeonardSapone2017 was invoked but never defined (see the help page).
and 30 Related for: Intestinal permeability information
Intestinalpermeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall...
intestinal permeability (a measure of intestinal barrier function). Modulating factors include cytokines, immune cells, and exogenous factors. Intestinal permeability...
their solubility and permeability. This system restricts the prediction using the parameters solubility and intestinalpermeability. The solubility classification...
unrecognized condition. Unlike the scientific phenomenon of increased intestinalpermeability ("leaky gut"), claims for the existence of "leaky gut syndrome"...
morphological changes to the microvillus, increased intestinalpermeability, and programmed cell death of small intestinal epithelial cells. Both trophozoites and...
of the genetic expression of autoimmunity, leading to increased intestinalpermeability of macromolecules. Zonula occludens toxin is being studied as an...
for lactose intolerance Sugar probes or 51Cr-EDTA to determine intestinalpermeability. D-xylose absorption test for mucosal disease or bacterial overgrowth...
chemistry, parallel artificial membrane permeability assay (PAMPA) is a method which determines the permeability of substances from a donor compartment...
inhibitor of paracellular permeability. In celiac disease, one pathway that allows fragments of gliadin protein to get past the intestinal epithelium and subsequently...
addition to increased intestinalpermeability are thought to play a role. Heavy alcohol consumption increases intestinalpermeability by causing direct damage...
responsible for regulating intestinal tight-junctions. His major research focus then shifted to the study of intestinalpermeability, the pathophysiology of...
blood levels, improving the intestinal transit time, decreasing small intestine permeability, and by treating small intestinal bacterial overgrowth of fermenting...
for coeliac disease: gluten detoxification, modulation of the intestinalpermeability, and modulation of the immune response. Using genetically engineered...
gut refers to: Increased intestinalpermeability, the phenomenon whereby the intestine wall exhibits excessive permeability Leaky gut syndrome, a hypothetical...
Berghe, Pieter Vanden; Tack, Jan; Farré, Ricard (2014-10-29). "From IntestinalPermeability to Dysmotility: The Biobreeding Rat as a Model for Functional Gastrointestinal...
increased intestinalpermeability causing protein to be lost from the interstitium into the intestinal lumen. This increased intestinalpermeability may be...
Interventional pulmonology, a less invasive lung treatment than surgery Intestinalpermeability Intraperitoneal injection (IP injection), the injection of a substance...
are limited and contradictory, since both increased intestinalpermeability and normal permeability have been documented in people with autism. Studies...
gut microbiome, cause or exacerbate inflammation, and increase intestinalpermeability. Other food additives in processed foods, such as xanthan gum,...
Kefir and Derived Pasteurized Beverages Modulate Gut Microbiota, IntestinalPermeability and Cytokine Production In Vitro Study of anti-inflammatory activity...
Coëffier, Moïse (January 2017). "Glutamine and the regulation of intestinalpermeability: from bench to bedside". Current Opinion in Clinical Nutrition...
significant antioxidant activities and also helps to maintain intestinalpermeability. It is able to suppress the growth of gas-producing bacteria in...
System which determines a drugs' attributes by solubility and intestinalpermeability. For the Canadian legal classification, see Controlled Drugs and...
the small bowel bacterial overgrowth syndrome and an increased intestinalpermeability. Lipid A may cause uncontrolled activation of mammalian immune...
postulates that increased intestinalpermeability contributes to PSC. Tight junctions, which normally maintain the integrity of the intestinal epithelium, may become...
Global Information