Category of drugs used to classify a drug according to certain criteria
This article is about pharmacological drug classification. For other uses, see Drug class (disambiguation).
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A drug class is a group of medications and other compounds that have similar chemical structures, the same mechanism of action (i.e. binding to the same biological target), similar modes of action, and/or are used to treat the similar diseases.[1][2] The Food and Drug Administration (FDA) has worked on classifying and licensing new medications for many years. However, the FDA's Drug Evaluation and Research Center categorizes these new medications based on both their chemical and therapeutic class.[3]
In several dominant drug classification systems, these four types of classifications form a hierarchy.[4] For example, the fibrates are a chemical class of drugs (amphipathic carboxylic acids) that share the same mechanism of action (PPAR agonist) and mode of action (reducing blood triglycerides), and that are used to prevent and treat the same disease (atherosclerosis). Conversely, not all PPAR agonists are fibrates, not all triglyceride lowering agents are PPAR agonists, and not all drugs used to treat atherosclerosis are triglyceride-lowering agents.
A drug class is typically defined by a prototype drug, the most important, and typically the first developed drug within the class, used as a reference for comparison.
^Mahoney A, Evans J (2008). "Comparing drug classification systems". AMIA Annual Symposium Proceedings: 1039. PMID 18999016.
^World Health Organization (2003). Introduction to drug utilization research(PDF). Geneva: World Health Organization. p. 33. ISBN 978-9241562348. Archived from the original (PDF) on June 5, 2010.
^Michael D. Sanborn, Harold N. Godwin, James D. Pessetto, FDA drug classification system, American Journal of Hospital Pharmacy, Volume 48, Issue 12, 1 December 1991, Pages 2659–2662, https://doi.org/10.1093/ajhp/48.12.2659
^Mahoney A, Evans J (November 2008). "Comparing drug classification systems". AMIA ... Annual Symposium Proceedings. AMIA Symposium: 1039. PMID 18999016.
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