The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic conditions like cancer and infection, along a diverse set of physiological circumstances of tissue damage or organ failure, including autoimmune disease or allograft rejection.[1] The identification of shared mechanisms and phenotypes by distinct immune pathologies, marked as a hallmarks or biomarkers, aids in the identification of novel treatment options, without necessarily assessing patients phenomenologies individually.
^Wang E, Worschech A, Marincola FM (June 2008). "The immunologic constant of rejection". Trends in Immunology. 29 (6): 256–62. doi:10.1016/j.it.2008.03.002. PMID 18457994.
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The ImmunologicConstantofRejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic...
when the immunological basis of the organ rejection process was described. The next waves of studies on the topic came with the discovery of immunosuppressive...
Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system's state of unresponsiveness to substances or tissues...
immunity creates an immunological memory leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity...
Billingham, he demonstrated the principle of acquired immunological tolerance (the phenomenon of unresponsiveness of the immune system to certain molecules)...
R.; Schuit, H. R.; Hijmans, W. (1965). "The immunological development of the human fetus". Journal of Experimental Medicine. 122 (6): 1173–88. doi:10...
encoded directly in germline), and are a manifestation ofimmunological memory. In the course of an immune response, B cells can progressively differentiate...
cornea of the eye is immunologically a very special tissue. Its constant exposure to the exterior world means that it is vulnerable to a wide range of microorganisms...
functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases...
periphery. Transparency, avascularity, the presence of immature resident immune cells, and immunologic privilege makes the cornea a very special tissue....
repurposed for explanations of the self/non-self model of the immune system. The immunologist Russell E. Vance has argued that immunological paradigms like the...
remove immunogenic content and to increase immunologic efficiency. This was initially achieved by the production of chimeric (suffix -ximab) and humanized...
cells help polarize the immune response depending on the nature of the immunological insult (for example; virus vs. extracellular bacterium vs. intracellular...
PMC 6690237. PMID 31435502. Hsu CJ, Wong LC, Lee WT (January 2021). "Immunological dysfunction in Tourette syndrome and related disorders". Int J Mol Sci...
physical and immunological threats. This is particularly beneficial for humans since offspring are dependent on parents for extended periods of time and mothers...
crucial for the maintenance ofimmunological tolerance. Their major role is to shut down T cell–mediated immunity toward the end of an immune reaction and...
embryo screened to be free of the disease before implantation with In vitro fertilization. The baby's supply ofimmunologically compatible cord blood was...
Pre-existing diversity is the engine of adaption in the evolution of populations. "It is clear from both evolutionary and immunological theory that in facing an unknown...
also certain types of fungi and viruses. They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells. In conducting...
obviously preferred as it reduces the risk ofimmunological reaction and rejectionof the foreign object. While many of the more advanced systems are not ready...
The Nature of Things (also, The Nature of Things with David Suzuki) is a Canadian television series of documentary programs. It debuted on CBC Television...
"Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil". Immunological Reviews. 136 (1): 5–28. doi:10.1111/j...
cells formation. Roifman's group was the first to identify immunological consequences of CD25 loss and the patient has suffered from chronic infections...
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