Hepatokines (Greek heapto-, liver; and -kinos, movement) are proteins produced by liver cells (hepatocytes) that are secreted into the circulation and function as hormones across the organism. Research is mostly focused on hepatokines that play a role in the regulation of metabolic diseases such as diabetes and fatty liver and include: Adropin, ANGPTL4, Fetuin-A, Fetuin-B, FGF-21, Hepassocin, LECT2, RBP4,Selenoprotein P, Sex hormone-binding globulin.[1]
Hepatokines (Greek heapto-, liver; and -kinos, movement) are proteins produced by liver cells (hepatocytes) that are secreted into the circulation and...
hepatocytes and secreted into the blood and constitute plasma proteins and hepatokines. Other liver-specific proteins are certain liver enzymes such as HAO1...
Increase hepatic production of binding proteins Increase production of the hepatokine adropin. Coagulation Increase circulating level of factors 2, 7, 9, 10...
been shown to be associated with excessive body weight. Adipose tissue Hepatokines Myokines Mancuso P (May 2016). "The role of adipokines in chronic inflammation"...
binding domain and thus can be released into the circulation. FGF21 is a hepatokine – i.e., a hormone secreted by the liver – that regulates simple sugar...
led by Andrew Butler, as a protein hormone, secreted from the liver (hepatokine), in the context of obesity and energy homeostasis. They derived the name...
Proteins produced by hepatocytes that function as hormones are known as hepatokines. The liver forms fatty acids from carbohydrates and synthesizes triglycerides...
exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. RBP4 has been a drug...
the fed state, likely through activation by Angptl8, a feeding-induced hepatokine, to inhibit postprandial LPL activity in cardiac and skeletal muscles...
"Proinflammatory and antiinflammatory attributes of fetuin-a: a novel hepatokine modulating cardiovascular and glycemic outcomes in metabolic syndrome"...
express LECT2 but do so under a variety of disease conditions. LECT2 as a hepatokine, a substance made and released into the circulation by liver hepatocyte...
enzymes. Additionally, the HepaRG cells have functional mitochondria, hepatokine secretion abilities, and a suitable response to insulin. One unique characteristic...
intestinal tissues. Human ANGPTL4 is most highly expressed in the liver as a hepatokine. This gene is induced under hypoxic (low oxygen) condition in various...
T-cell leukemia SKW-3 cells. Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte...
broadinstitute.org. Retrieved 2018-05-06. "FAM71E1- Type 2 diabetes and role of hepatokines". www.ncbi.nlm.nih.gov. Momcilovic O, Sivapatham R, Oron TR, Meyer M...
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