negative regulation of lipoprotein lipase activity
cell differentiation
negative regulation of endothelial cell apoptotic process
negative regulation of apoptotic process
response to hypoxia
protein homooligomerization
angiogenesis
triglyceride homeostasis
positive regulation of angiogenesis
regulation of lipid metabolic process
lipid metabolism
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51129
57875
Ensembl
ENSG00000167772
ENSMUSG00000002289
UniProt
Q9BY76
Q9Z1P8
RefSeq (mRNA)
NM_001039667 NM_016109 NM_139314
NM_020581
RefSeq (protein)
NP_001034756 NP_647475
NP_065606
Location (UCSC)
Chr 19: 8.36 – 8.37 Mb
Chr 17: 33.99 – 34 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Angiopoietin-like 4 is a protein that in humans is encoded by the ANGPTL4 gene.[5][6][7] Alternatively spliced transcript variants encoded with different isoforms have been described. This gene was previously referred to as ANGPTL2, HFARP, PGAR, or FIAF but has been renamed ANGPTL4.
This gene is induced under hypoxic (low oxygen) condition in various cell types and is the target of peroxisome proliferator-activated receptors. The encoded protein is a serum hormone directly involved in regulating lipid metabolism.
ANGPTL4 plays an important role in numerous cancers and is implicated in the metastatic process by modulating vascular permeability, cancer cell motility and invasiveness.[8][9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000167772 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002289 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kim I, Kim HG, Kim H, Kim HH, Park SK, Uhm CS, et al. (March 2000). "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis". The Biochemical Journal. 346 (Pt 3): 603–10. doi:10.1042/0264-6021:3460603. PMC 1220891. PMID 10698685.
^Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, et al. (July 2000). "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation". Molecular and Cellular Biology. 20 (14): 5343–9. doi:10.1128/MCB.20.14.5343-5349.2000. PMC 85983. PMID 10866690.
^Kersten S, Mandard S, Tan NS, Escher P, Metzger D, Chambon P, et al. (September 2000). "Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene" (PDF). The Journal of Biological Chemistry. 275 (37): 28488–93. doi:10.1074/jbc.M004029200. PMID 10862772.
^Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, et al. (April 2008). "TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4". Cell. 133 (1): 66–77. doi:10.1016/j.cell.2008.01.046. PMC 2390892. PMID 18394990.
^Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN (November 2011). "ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression". Cancer Research. 71 (22): 7010–20. doi:10.1158/0008-5472.CAN-11-1262. PMC 3217078. PMID 21937683.
^Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, et al. (October 2013). "Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion". Oncogene. 32 (44): 5241–52. doi:10.1038/onc.2012.549. PMC 3938163. PMID 23208498.
Angiopoietin-like 4 is a protein that in humans is encoded by the ANGPTL4 gene. Alternatively spliced transcript variants encoded with different isoforms...
in controlling the activity of LPL is ANGPTL4, which serves as a local inhibitor of LPL. Induction of ANGPTL4 accounts for the inhibition of LPL activity...
Diet and heart disease Fast food Junk food Advanced glycation endproduct ANGPTL4 Iodine value Framingham Heart Study Seven Countries Study Ancel Keys D...
to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to...
FIAF may refer to: Fasting-Induced Adipose Factor or ANGPTL4, a protein Fédération Internationale des Archives du Film or International Federation of...
metabolic diseases such as diabetes and fatty liver and include: Adropin, ANGPTL4, Fetuin-A, Fetuin-B, FGF-21, Hepassocin, LECT2, RBP4,Selenoprotein P, Sex...
name betatrophin continues to be used. Given the homology of ANGPTL8 with ANGPTL4 and ANGPTL3, and considering that ANGPTL8 does not promote beta cell proliferation...