Global InformationLECT2 amyloidosis information
| LECT2 amyloidosis | |
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| Example of amyloid deposits under Congo Red staining |
LECT2 Amyloidosis (ALECT2) is a form of amyloidosis caused by the LECT2 protein. It was found to be the third most common (~3% of total) cause of amyloidosis in a set of more than 4,000 individuals studied at the Mayo Clinic; the first and second most common forms the disorder were AL amyloidosis and AA amyloidosis, respectively. Amyloidosis is a disorder in which the abnormal deposition of a protein in organs and/or tissues gradually leads to organ failure and/or tissue injury.[1][2][3]
Although more than 30 different proteins can cause amyloidosis, the disorder caused by LECT2 is distinctive in three ways. First, it has an unusually high incidence in certain ethnic populations. Second, it is a systemic form of amyloidosis (i.e. amyloid deposited in multiple organs), as opposed to a localized form (amyloid deposits limited to a single organ) but nonetheless injures the kidney without or rarely injuring the other organs in which it is deposited. Third, LECT2 amyloidosis is diagnosed almost exclusively in elderly individuals.[2]
Given its relatively recent discovery, exceptionally strong ethnic bias, limitation to causing kidney disease, and restriction to elderly individuals, LECT2 amyloidosis appears at present to be an under-recognized cause of chronic kidney disease particularly in the ethnic groups that exhibit a high incidence of the disorder.[4]
- ^ Picken, M. (Aug 2014). "Alect2 amyloidosis: Primum non nocere (first, do no harm)". Kidney Int. 86 (2): 229–232. doi:10.1038/ki.2014.45. PMID 25079018.
- ^ a b Cite error: The named reference
pmid28466965was invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid28621339was invoked but never defined (see the help page). - ^ Larsen CP, Beggs ML, Wilson JD, Lathrop SL (2016). "Prevalence and organ distribution of leukocyte chemotactic factor 2 amyloidosis (ALECT2) among decedents in New Mexico". Amyloid. 23 (2): 119–23. doi:10.3109/13506129.2016.1145110. PMC 4898138. PMID 26912093.