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HepaRG information


Fully differentiated HepaRGTM cells organized in well-delineated trabeculae with many bright canaliculi-like structures.

HepaRG cell line is a human hepatic in vitro line used in liver biology research and for assessing liver pathology, hepatotoxicity, and drug-induced injury. The HepaRG model is considered a surrogate for Primary Human Hepatocytes, which are the most pertinent model to reproduce the human liver functioning as they express 99% of the same genes.

In contrast to the historic hepatic line HepG2, HepaRG cells preserved various liver-specific functions, including the expression of CYP enzymes and transporters, the formation of bile canaliculi, and, the ability to be applied in 2D and 3D configuration.

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HepaRG

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HepaRG cell line is a human hepatic in vitro line used in liver biology research and for assessing liver pathology, hepatotoxicity, and drug-induced injury...

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Metronidazole

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2015). "Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes". Xenobiotica; the Fate of Foreign...

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In vitro

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plated cultures of primary hepatocytes or hepatocyte-like cell lines (HepG2, HepaRG) can be used to study and quantify metabolism of chemicals. These ADME process...

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CccDNA

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types: primary tupaia, or human hepatocytes (PHH), and differentiated HepaRG (dHepaRG). It is from these models that HBV replication was observed via transcription...

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Pyrrolizidine alkaloid

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Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells". Oxidative Medicine and Cellular Longevity. 2021: e8822304. doi:10...

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CYP2C9

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2015). "Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes". Xenobiotica; the Fate of Foreign...

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Microplastics effects on human health

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(NTRC) show local exhaust ventilation and High Efficiency Particulate Air (HEPA) filtration to be effective mitigation to theoretically filter 99.97% of...

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Artificial organ

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difficulties in getting blood vessels and lab-made tissues to function cohesively. HepaLife is developing a bioartificial liver device intended for the treatment...

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Underfloor heating

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Anthropology and Applied Human Science, 23: 205–213, 2004 Springer, W. E., Nevins, R.G., Feyerherm, A.M., Michaels, K.B., Effect of floor surface temperature on...

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WELL Building Standard

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liquid soap through sealed dispensers, paper towels or hand dryers with HEPA filter or fabric towel rolls and signage with proper hand washing steps....

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Ultraviolet germicidal irradiation

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protocols are typically used, especially in wastewater reuse applications. HEPA filter Portable water purification Sanitation Sanitation Standard Operating...

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Aryl hydrocarbon receptor

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hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells". Molecular Pharmacology. 52 (4): 590–599. doi:10.1124/mol.52...

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Inflammatory demyelinating diseases of the central nervous system

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still no agreement on their relevance: HEPACAM: A cross-reactivity between HepaCam (GlialCam) and EBNA1 has been reported as of 2022 on 25% of MS cases Anti-kir4...

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