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Hepatic fructokinase information


ketohexokinase (fructokinase)
Ketohexokinase homodimer, Human
Identifiers
SymbolKHK
NCBI gene3795
HGNC6315
OMIM229800
RefSeqNM_006488
UniProtP50053
Other data
EC number2.7.1.3
LocusChr. 2 p23.3-23.2
Search for
StructuresSwiss-model
DomainsInterPro
Ketohexokinase
Identifiers
EC no.2.7.1.3
CAS no.9030-50-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.

ATP + Fru    ADP + F1P
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]
  1. ^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. doi:10.1042/bj2300053. PMC 1152585. PMID 2996495.

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Hepatic fructokinase

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Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate. ATP +   ⟶ {\displaystyle...

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diagnosis of fructosuria are hepatic fructokinase deficiency, levulosuria and ketohexokinase deficiency. Hepatic fructokinase PFKL PFKM PFKP Glucokinase...

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Essential fructosuria

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Essential fructosuria, caused by a deficiency of the enzyme hepatic fructokinase, is a clinically benign condition characterized by the incomplete metabolism...

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Inborn errors of carbohydrate metabolism

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encoding hepatic fructokinase, an enzyme that catalyzes the first step in the metabolism of dietary fructose. Inactivation of the hepatic fructokinase results...

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Fructose

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liver by fructokinase (Km= 0.5 mM) and galactokinase (Km = 0.8 mM), respectively. By contrast, glucose tends to pass through the liver (Km of hepatic glucokinase...

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fructose is the phosphorylation of fructose to fructose 1-phosphate by fructokinase (Km = 0.5 mM, ≈ 9 mg/100 ml), thus trapping fructose for metabolism in...

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Glucokinase

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concentration rises, it serves as a central metabolic switch to shift hepatic carbohydrate metabolism between fed and fasting states. Phosphorylation...

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Phosphofructokinase 2

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family described here bears a resemblance to the ATP-driven phospho-fructokinases; however, they share little sequence similarity, although a few residues...

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Adenosine kinase

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as the RK family) include ribokinase (RK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified...

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Aldolase B

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intestinal mucosa. When fructose is absorbed, it is phosphorylated by fructokinase to form fructose 1-phosphate. Aldolase B then catalyzes F1P breakdown...

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