fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose 1,6-bisphosphate metabolic process
NADH oxidation
fructose metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
229
230163
Ensembl
ENSG00000136872
ENSMUSG00000028307
UniProt
P05062
Q91Y97
RefSeq (mRNA)
NM_000035
NM_144903
RefSeq (protein)
NP_000026
NP_659152
Location (UCSC)
Chr 9: 101.42 – 101.45 Mb
Chr 4: 49.54 – 49.55 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP.[5]
In humans, aldolase B is encoded by the ALDOB gene located on chromosome 9. The gene is 14,500 base pairs long and contains 9 exons.[6][7][8] Defects in this gene have been identified as the cause of hereditary fructose intolerance (HFI).[9]
^ abcGRCh38: Ensembl release 89: ENSG00000136872 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028307 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dalby AR, Tolan DR, Littlechild JA (November 2001). "The structure of human liver fructose-1,6-bisphosphate aldolase". Acta Crystallogr. D. 57 (Pt 11): 1526–33. doi:10.1107/S0907444901012719. PMID 11679716.
^Henry I, Gallano P, Besmond C, Weil D, Mattei MG, Turleau C, Boué J, Kahn A, Junien C (July 1985). "The structural gene for aldolase B (ALDB) maps to 9q13----32". Ann. Hum. Genet. 49 (Pt 3): 173–80. doi:10.1111/j.1469-1809.1985.tb01691.x. PMID 3000275. S2CID 10058239.
^Tolan DR, Penhoet EE (June 1986). "Characterization of the human aldolase B gene". Mol. Biol. Med. 3 (3): 245–64. PMID 3016456.
^Cox TM (January 1994). "Aldolase B and fructose intolerance". FASEB J. 8 (1): 62–71. doi:10.1096/fasebj.8.1.8299892. PMID 8299892. S2CID 39102274.
AldolaseB also known as fructose-bisphosphate aldolaseB or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate...
inborn error of fructose metabolism caused by a deficiency of the enzyme aldolaseB. Individuals affected with HFI are asymptomatic until they ingest fructose...
Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the ALDOA gene on chromosome 16....
Unqualified, aldolase usually refers to the enzyme fructose-bisphosphate aldolase. Aldolase may also refer to: Aldolase A AldolaseBAldolase C 17a-hydroxyprogesterone...
fructokinase initially produces fructose 1-phosphate, which is split by aldolaseB to produce the trioses dihydroxyacetone phosphate (DHAP) and glyceraldehyde...
Fructose-1-phosphate then undergoes hydrolysis by fructose-1-phosphate aldolase (aldolaseB) to form dihydroxyacetone phosphate (DHAP) and glyceraldehyde; DHAP...
Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme that, in humans, is encoded by the ALDOC gene on chromosome 17. This gene encodes a member...
and death. HFI is caused by a deficiency of fructose 1,6-biphosphate aldolase in the liver, kidney cortex and small intestine. Infants and adults are...
Aldolase A deficiency is an autosomal recessive metabolic disorder resulting in a deficiency of the enzyme aldolase A; the enzyme is found predominantly...
of fructose in the blood (fructosemia), is caused by a deficiency of aldolaseB, the second enzyme involved in the metabolism of fructose. [citation needed]...
et al. (February 2004). "Genes encoding Pir51, Beclin 1, RbAp48 and aldolaseb are up or down-regulated in human primary hepatocellular carcinoma". World...
They are Nε-trimethyllysine hydroxylase, 3-hydroxy-Nε-trimethyllysine aldolase, 4-N-trimethylaminobutyraldehyde dehydrogenase and γ-butyrobetaine hydroxylase...
The enzyme dihydroneopterin aldolase (EC 4.1.2.25) catalyzes the chemical reaction 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine...
dihydroxyacetone phosphate (DHAP), also a 3-carbon molecule.[citation needed] Aldolase and fructose-1,6-bisphosphatase convert a G3P and a DHAP into fructose...
bifunctional heterodimer with metal-dependent 4-hydroxy-2-ketovalerate aldolase. Utilized in the bacterial degradation of toxic aromatic compounds, the...
contain a bifunctional fructose 1,6-bisphosphate (FBP) aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity. This enzyme is missing...
1970, Freeze and Brock published an article describing a thermostable aldolase enzyme from T. aquaticus. The first polymerase enzyme isolated from T....
formation using the free amine from a lysine residue, as seen in the enzyme aldolase during glycolysis. Some enzymes utilize non-amino acid cofactors such as...
doi:10.1021/bi049892w. PMID 15147206. Meier B, Döbeli H, Certa U (1992). "Stage-specific expression of aldolase isoenzymes in the rodent malaria parasite...
intermediate complex of transaldolase B from Escherichia coli: mechanistic implications for class I aldolases". Protein Sci. 6 (1): 119–24. doi:10.1002/pro...
(addition) stage of the process—the aldol reaction itself—as catalyzed by aldolases. However, the first step is formally an addition reaction rather than...