This article is about Fructokinase (EC 2.7.1.4). For the hepatic enzyme, whose deficiency is associated with essential fructosuria, see Hepatic fructokinase.
Fructokinase
Fructokinase dimer, Bacillus subtilis
Identifiers
EC no.
2.7.1.4
CAS no.
9030-51-7
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Fructokinase (/fruc•to•ki•nase/ [-ki´nas]), also known as D-fructokinase or D-fructose (D-mannose) kinase,[1] is an enzyme (EC 2.7.1.4) of the liver, intestine, and kidney cortex. Fructokinase is in a family of enzymes called transferases, meaning that this enzyme transfers functional groups; it is also considered a phosphotransferase (or, frequently, a kinase) since it specifically transfers a phosphate group.[1] Fructokinase specifically catalyzes the transfer of a phosphate group from adenosine triphosphate (ATP, the substrate) to fructose as the initial step in its utilization.[1] The main role of fructokinase is in carbohydrate metabolism, more specifically, sucrose and fructose metabolism. The reaction equation is as follows:
ATP + D-fructose → ADP + D-fructose 1-phosphate.
^ abcDBGET ENZYME: 2.7.1.4 Archived 27 September 2007 at the Wayback Machine. Retrieved 2007-05-06
Fructokinase (/fruc•to•ki•nase/ [-ki´nas]), also known as D-fructokinase or D-fructose (D-mannose) kinase, is an enzyme (EC 2.7.1.4) of the liver, intestine...
Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate. ATP + ⟶ {\displaystyle...
is converted to fructose-1-phosphate in the liver by fructokinase. Deficiencies of fructokinase cause essential fructosuria, a clinically benign condition...
transporter. Fructose and galactose are phosphorylated in the liver by fructokinase (Km= 0.5 mM) and galactokinase (Km = 0.8 mM), respectively. By contrast...
Essential fructosuria, caused by a deficiency of the enzyme hepatic fructokinase, is a clinically benign condition characterized by the incomplete metabolism...
fructose is the phosphorylation of fructose to fructose 1-phosphate by fructokinase (Km = 0.5 mM, ≈ 9 mg/100 ml), thus trapping fructose for metabolism in...
which plays an important role as an allosteric activator of phospho-fructokinase 1 (PFK-1). PFK-1 is an enzyme that controls one of the most critical...
RK family) include adenosine kinase (AK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified...
adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases". Proceedings of the National Academy of Sciences of the United States...
the Ribokinase family) include ribokinase (RK) adenosine kinase (AK), fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified...
as the RK family) include ribokinase (RK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified...
Röda Kors) Frankish language Frégate Island Airport, in the Seychelles Fructokinase Funmilayo Ransome-Kuti Fyn-related kinase Martin Frk (born 1993), Czech...
hepatic fructokinase, an enzyme that catalyzes the first step in the metabolism of dietary fructose. Inactivation of the hepatic fructokinase results...
and fructose. Fructose is usually digested outside the hyphae using fructokinase activity, whereas glucose enters the cell undigested for cellular metabolism...
Jianxin; Lu, Zhimin (April 16, 2019). "The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating...
intestinal mucosa. When fructose is absorbed, it is phosphorylated by fructokinase to form fructose 1-phosphate. Aldolase B then catalyzes F1P breakdown...
family described here bears a resemblance to the ATP-driven phospho-fructokinases; however, they share little sequence similarity, although a few residues...
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