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Medical condition
Hemoglobinuria
Other names
Haemoglobinuria
Structure of hemoglobin
Specialty
Urology, nephrology
Symptoms
Disease, Hemolytic anemia, Proteinuria
Causes
Acute glomerulonephritis; Burns; Renal cancer; Malaria; Paroxysmal nocturnal hemoglobinuria; Microangiopathies, e.g. hemolytic-uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP) leading to microangiopathic hemolytic anemia; Transfusion reactions; IgM autoimmune hemolytic anemia; Glucose-6-phosphate dehydrogenase deficiency; Pyelonephritis; Sickle cell anemia; Tuberculosis of the urinary tract; March hemoglobinuria secondary to repetitive impacts on the body, usually the feet; Athletic nephritis secondary to strenuous exercise; Acute lead poisoning
Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine.[1] The condition is caused by excessive intravascular hemolysis, in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma.[2] Excess hemoglobin is filtered by the kidneys, which excrete it into the urine, giving urine a purple color. Hemoglobinuria can lead to acute tubular necrosis which is an uncommon cause of a death of uni-traumatic patients recovering in the ICU.
^Deters, A.; Kulozik, A. E. (2003). "Hemoglobinuria". Practical Algorithms in Pediatric Hematology and Oncology. 7 (2–3): 20–21. doi:10.1159/000069582. ISBN 3-8055-7432-0. Retrieved 20 October 2019.
^Harper, James L (30 September 2020). "What causes hemoglobinuria?". www.medscape.com. Retrieved 5 April 2021.
Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. The condition is...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening disease of the blood characterized by destruction of red blood cells by...
inhibitor medication designed for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. It is designed to bind...
Empaveli, among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria and geographic atrophy of the retina. Pegcetacoplan is a complement...
Paroxysmal cold hemoglobinuria (PCH) or Donath–Landsteiner hemolytic anemia (DLHA) is an autoimmune hemolytic anemia featured by complement-mediated intravascular...
Exertional hemoglobinuria (or exercise hematuria) may refer to: March hemoglobinuria caused by impacts upon the body Hemoglobinuria secondary to athletic...
Paroxysmal hemoglobinuria can refer to: Paroxysmal nocturnal hemoglobinuria Paroxysmal cold hemoglobinuriaHemoglobinuria This disambiguation page lists...
may result in hemoglobinuria. The damage is induced through repetitive mechanical motions such as prolonged marching (march hemoglobinuria) and marathon...
Fabhalta, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement factor B inhibitor that was developed by Novartis...
Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to...
investigation by Roche/Genentech for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Following an initial i.v. loading dose, crovalimab is administered...
presentation must be excluded, such as aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia and leukemias. This requires a bone marrow examination...
which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath–Landsteiner hemolytic anemia, and vasculitis...
a result of certain infections (e.g. malaria). Paroxysmal nocturnal hemoglobinuria (PNH), sometimes referred to as Marchiafava-Micheli syndrome, is a rare...
serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from somatic...
diagnostic laboratory test used for diagnosing paroxysmal nocturnal hemoglobinuria (PNH), as well as for hypoplastic anemias and any hemolytic anemia with...
hemoglobin (hemoglobinuria). Blood present in large quantities can be detected visually. Hematuria produces cloudy red urine, and hemoglobinuria appears as...
test is a blood test used in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). Patient red blood cells (RBCs) are placed in mild acid; a positive...
malaria, tabes dorsalis, and Behçet's disease, paroxysmal nocturnal hemoglobinuria (PNH). It has also been noted as a symptom of gratification disorder...
exercise. Bloody urine after strenuous exercise may also result from march hemoglobinuria, which is caused by trauma to red blood cells, causing their rupture...
Antibody test: immune competency Blood tests for paroxysmal nocturnal hemoglobinuria Bone marrow aspirate and biopsy: to rule out other causes of pancytopenia...
due to the failure of the liver to metabolize the excess bilirubin. Hemoglobinuria is seen due to excretion of red-blood-cell lysis byproducts via the...
cause premature destruction. All of these, except paroxysmal nocturnal hemoglobinuria, are hereditary genetic disorders. Hereditary spherocytosis is a hereditary...
cause). Red cell agglutination can also occur in paroxysmal nocturnal hemoglobinuria: 13 and warm autoimmune hemolytic anemia.: 88 In cases of red cell...
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