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Cold sensitive antibodies information


Cold sensitive antibodies
Other namesCold reactive antibodies, cold reacting antibodies
SpecialtyHematology

Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder. These pathological cold sensitive antibodies include cold agglutinins, Donath–Landsteiner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath–Landsteiner hemolytic anemia, and vasculitis, respectively.

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Cold sensitive antibodies

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Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder...

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Cold agglutinin disease

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Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies...

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Cryoglobulinemia

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condition in which the blood contains large amounts of pathological cold sensitive antibodies called cryoglobulins – proteins (mostly immunoglobulins themselves)...

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Paroxysmal cold hemoglobinuria

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Donath–Landsteiner antibody is clearly pathognomonic for the DLHA. Anemia of prematurity Cold agglutinin disease Cold sensitive antibody Fanconi anemia Hemolytic...

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Radioimmunoassay

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example, hormone levels in blood) by use of antibodies. Although the RIA technique is extremely sensitive and extremely specific, requiring specialized...

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Cold sore

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A cold sore (also known as a fever blister, oral herpes, and herpes labialis) is a type of herpes infection caused by the herpes simplex virus that affects...

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Infectious mononucleosis

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90% of diagnosed people have heterophile antibodies by week 3, disappearing in under a year. The antibodies involved in the test do not interact with...

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Autoantibody

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diseases (notably lupus erythematosus) are associated with such antibodies. Antibodies are produced by B cells in two ways: (i) randomly, and (ii) in response...

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Immunohistochemistry

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improve the IHC signal. Non-specific binding of antibodies can cause background staining. Although antibodies bind to specific epitopes, they may also partially...

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Respiratory syncytial virus

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target for neutralizing antibodies, but its variability enables viral evasion from neutralization, affecting the efficacy of antibodies like Palivizumab. Cross-reactions...

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Coeliac disease

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transglutaminase (IgG-tTG) may be diagnostic. If all these antibodies are negative, then anti-DGP antibodies (antibodies against deamidated gliadin peptides) should...

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Mixed autoimmune hemolytic anemia

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of autoimmune hemolytic anemia which combines the features of cold sensitive antibody-induced diseases and warm autoimmune hemolytic anemia. The work-up...

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Pernicious anemia

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indicated that the formation of antibodies to gastric cells was autosomal dominant gene determined, and the presence of antibodies to the gastric cells might...

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Laboratory diagnosis of viral infections

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will produce antibodies in their bloodstream that specifically recognize that virus. This is called humoral immunity. Two types of antibodies are important...

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Viral envelope

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by inducing antibodies that prevent the pathogen from entering cells. This happens in the case of enveloped viruses when the antibodies bind to the viral...

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Julius Youngner

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vaccinate, and 3. safety testing for batches of vaccine and anti-polio antibodies in test subjects. or in the words of his colleague: "“Juli figured out...

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Omalizumab

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kinetics, rendering those cells much less sensitive to stimulation by allergens. Thus, therapeutic anti-IgE antibodies such as omalizumab represent a new class...

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Hives

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the skin and tissues in response to the binding of allergen-bound IgE antibodies to high-affinity cell surface receptors. Basophils and other inflammatory...

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Ficus benjamina

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growth in a short time. It does not need to be misted. The plant is sensitive to cold and should be protected from strong drafts. When grown indoors, it...

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Hot start PCR

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such as: Enzyme linked antibodies/Taq DNA polymerase complexed with Anti Taq DNA polymerase antibodies: The enzyme linked antibodies inactivate the Taq DNA...

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Pepsin

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antibodies, causing background staining in areas that do not contain the target antigen. Use of F(ab')2 or Fab fragments ensures that the antibodies are...

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Man flu

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that men experience more severe symptoms when afflicted with the common cold or flu-like illnesses. Primarily British, it is frequently used in a self-deprecating...

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Raynaud syndrome

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specific causative illnesses or an inflammatory process. Anti-centromere antibodies are common in limited systemic sclerosis (CREST syndrome). Nail fold vasculature...

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Lupus

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antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE) and anti-histone antibodies (which are...

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Fifth disease

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Anti-parvovirus B19 IgM antibody serum assay is the preferred method to detect previous infection. An antibody assay uses antibodies designed to detect parvovirus...

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ISFET

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An ion-sensitive field-effect transistor (ISFET) is a field-effect transistor used for measuring ion concentrations in solution; when the ion concentration...

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Aptamer

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structure of antibodies, which are proteins. This difference can make aptamers a better choice than antibodies for some purposes (see antibody replacement)...

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Moraxella catarrhalis

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the surface of M. catarrhalis that may serve as a target for protective antibodies. This UspA (the designated antigen) protein is the first surface-exposed...

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